Helen & Robert Appel Alzheimer’s Disease Research Institute

You are here

TitleCell Biology and Pathophysiology of α-Synuclein.
Publication TypeJournal Article
Year of Publication2017
AuthorsBurré J, Sharma M, Südhof TC
JournalCold Spring Harb Perspect Med
Date Published2017 Jan 20
ISSN2157-1422
Abstract

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) and other neurodegenerative disorders. Accumulation of misfolded oligomers and larger aggregates of α-synuclein defines multiple neurodegenerative diseases called synucleinopathies, but the mechanisms by which α-synuclein acts in neurodegeneration are unknown. Moreover, the normal cellular function of α-synuclein remains debated. In this perspective, we review the structural characteristics of α-synuclein, its developmental expression pattern, its cellular and subcellular localization, and its function in neurons. We also discuss recent progress on secretion of α-synuclein, which may contribute to its interneuronal spread in a prion-like fashion, and describe the neurotoxic effects of α-synuclein that are thought to be responsible for its role in neurodegeneration.

DOI10.1101/cshperspect.a024091
Alternate JournalCold Spring Harb Perspect Med
PubMed ID28108534
Grant ListP50 NS094733 / NS / NINDS NIH HHS / United States
R01 AG052505 / AG / NIA NIH HHS / United States