Helen & Robert Appel Alzheimer’s Disease Research Institute

You are here

TitleMedicines for the mind: policy-based "pull" incentives for creating breakthrough CNS drugs.
Publication TypeJournal Article
Year of Publication2014
AuthorsChoi DW, Armitage R, Brady LS, Coetzee T, Fisher W, Hyman S, Pande A, Paul S, Potter W, Roin B, Sherer T
JournalNeuron
Volume84
Issue3
Pagination554-63
Date Published2014 Nov 5
ISSN1097-4199
KeywordsAnimals, Central Nervous System Agents, Health Policy, Health Services Needs and Demand, Humans, Motivation, Nervous System Diseases
Abstract

Several large pharmaceutical companies have selectively downsized their neuroscience research divisions, reflecting a growing view that developing drugs to treat brain diseases is more difficult and often more time-consuming and expensive than developing drugs for other therapeutic areas, and thus represents a weak area for investment. These withdrawals reduce global neuroscience translational capabilities and pose a serious challenge to society's interests in ameliorating the impact of nervous system diseases. While the path forward ultimately lies in improving understandings of disease mechanisms, many promising therapeutic approaches have already been identified, and rebalancing the underlying risk/reward calculus could help keep companies engaged in making CNS drugs. One way to do this that would not require upfront funding is to change the policies that regulate market returns for the most-needed breakthrough drugs. The broader neuroscience community including clinicians and patients should convene to develop and advocate for such policy changes.

DOI10.1016/j.neuron.2014.10.027
Alternate JournalNeuron
PubMed ID25442934