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TitleThe role of ERK1, 2, and 5 in dopamine neuron survival during aging.
Publication TypeJournal Article
Year of Publication2014
AuthorsParmar MS, Jaumotte JD, Wyrostek SL, Zigmond MJ, Cavanaugh JE
JournalNeurobiol Aging
Volume35
Issue3
Pagination669-79
Date Published2014 Mar
ISSN1558-1497
Abstract

Extracellular signal-regulated kinases (ERKs) 1, 2, and 5 have been shown to play distinct roles in proliferation, differentiation, and neuronal viability. In this study, we examined ERK1, 2, and 5 expression and activation in the substantia nigra (SN), striatum (STR), and ventral tegmental area (VTA) during aging. An age-related decrease in phosphorylated ERK5 was observed in the SN and STR, whereas an increase in total ERK1 was observed in all 3 regions. In primary cultures of the SN and VTA, inhibition of ERK5 but not ERK1 and 2 decreased dopamine neuronal viability significantly. These data suggest that ERK5 is essential for the basal survival of SN and VTA dopaminergic neurons. This is the first study to examine ERK1, 2, and 5 expression and activation in the SN, STR, and VTA during aging, and the relative roles of ERK1, 2, and 5 in basal survival of SN and VTA dopaminergic neurons. These data raise the possibility that a decline in ERK5 signaling may play a role in age-related impairments in dopaminergic function.

DOI10.1016/j.neurobiolaging.2013.09.031
Alternate JournalNeurobiol. Aging
PubMed ID24411019
PubMed Central IDPMC3896870
Grant ListAG25848 / AG / NIA NIH HHS / United States
NS070825 / NS / NINDS NIH HHS / United States
R01 NS070825 / NS / NINDS NIH HHS / United States