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B
Bacaj T
,
Wu D
,
Burré J
,
Malenka RC
,
Liu X
,
Südhof TC
. 2015.
Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.
.
PLoS Biol. 13(10):e1002267.
Bales KR
,
Verina T
,
Cummins DJ
,
Du Y
,
Dodel RC
,
Saura J
,
Fishman CE
,
DeLong CA
,
Piccardo P
,
Petegnief V
et al.
. 1999.
Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.
.
Proc Natl Acad Sci U S A. 96(26):15233-8.
Bales KR
,
Tzavara ET
,
Wu S
,
Wade MR
,
Bymaster FP
,
Paul SM
,
Nomikos GG
. 2006.
Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody.
.
J Clin Invest. 116(3):825-32.
Burré J
,
Sharma M
,
Südhof TC
. 2012.
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities.
.
J Neurosci. 32(43):15227-42.
C
Cirrito JR
,
Yamada KA
,
Finn MBeth
,
Sloviter RS
,
Bales KR
,
May PC
,
Schoepp DD
,
Paul SM
,
Mennerick S
,
Holtzman DM
. 2005.
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
.
Neuron. 48(6):913-22.
D
DeMattos RB
,
Bales KR
,
Cummins DJ
,
Paul SM
,
Holtzman DM
. 2002.
Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.
.
Science. 295(5563):2264-7.
Dodart J-C
,
Marr RA
,
Koistinaho M
,
Gregersen BM
,
Malkani S
,
Verma IM
,
Paul SM
. 2005.
Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.
.
Proc Natl Acad Sci U S A. 102(4):1211-6.
E
Etherton MR
,
Tabuchi K
,
Sharma M
,
Ko J
,
Südhof TC
. 2011.
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
.
EMBO J. 30(14):2908-19.
F
Fagan AM
,
Watson M
,
Parsadanian M
,
Bales KR
,
Paul SM
,
Holtzman DM
. 2002.
Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.
.
Neurobiol Dis. 9(3):305-18.
H
Holtzman DM
,
Bales KR
,
Tenkova T
,
Fagan AM
,
Parsadanian M
,
Sartorius LJ
,
Mackey B
,
Olney J
,
McKeel D
,
Wozniak D
et al.
. 2000.
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.
.
Proc Natl Acad Sci U S A. 97(6):2892-7.
Hunter JM
,
Cirrito JR
,
Restivo JL
,
Kinley RD
,
Sullivan PM
,
Holtzman DM
,
Koger D
,
DeLong C
,
Lin S
,
Zhao L
et al.
. 2012.
Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.
.
Brain Res. 1467:120-32.
I
Inda MCarmen
,
Joshi S
,
Wang T
,
Bolaender A
,
Gandu S
,
Iii JKoren
,
Che AYue
,
Taldone T
,
Yan P
,
Sun W
et al.
. 2020.
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
.
Nat Commun. 11(1):319.
K
Kauppinen TM
,
Suh SWon
,
Higashi Y
,
Berman AE
,
Escartin C
,
Won SJoon
,
Wang C
,
Cho S-H
,
Gan L
,
Swanson RA
. 2011.
Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.
.
J Neuroinflammation. 8:152.
L
Lee SHun
,
Sharma M
,
Südhof TC
,
Shen J
. 2014.
Synaptic function of nicastrin in hippocampal neurons.
.
Proc Natl Acad Sci U S A. 111(24):8973-8.
Linsenbardt AJ
,
Taylor A
,
Emnett CM
,
Doherty JJ
,
Krishnan K
,
Covey DF
,
Paul SM
,
Zorumski CF
,
Mennerick S
. 2014.
Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.
.
Neuropharmacology. 85:232-42.
M
Majewska MD
,
Harrison NL
,
Schwartz RD
,
Barker JL
,
Paul SM
. 1986.
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.
.
Science. 232(4753):1004-7.
Mannaioni G
,
Orr AG
,
Hamill CE
,
Yuan H
,
Pedone KH
,
McCoy KL
,
Palmini RBerlinguer
,
Junge CE
,
C Lee J
,
Yepes M
et al.
. 2008.
Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1.
.
J Biol Chem. 283(29):20600-11.
Mecozzi VJ
,
Berman DE
,
Simoes S
,
Vetanovetz C
,
Awal MR
,
Patel VM
,
Schneider RT
,
Petsko GA
,
Ringe D
,
Small SA
. 2014.
Pharmacological chaperones stabilize retromer to limit APP processing.
.
Nat Chem Biol. 10(6):443-9.
P
Pathak D
,
Berthet A
,
Bendor JT
,
Yu K
,
Sellnow RC
,
Orr AL
,
Nguyen MK
,
Edwards RH
,
Manfredsson FP
,
Nakamura K
. 2017.
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.
.
eNeuro. 4(2)
Paul SM
,
Doherty JJ
,
Robichaud AJ
,
Belfort GM
,
Chow BY
,
Hammond RS
,
Crawford DC
,
Linsenbardt AJ
,
Shu H-J
,
Izumi Y
et al.
. 2013.
The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.
.
J Neurosci. 33(44):17290-300.
S
Sun B
,
Halabisky B
,
Zhou Y
,
Palop JJ
,
Yu G
,
Mucke L
,
Gan L
. 2009.
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.
.
Cell Stem Cell. 5(6):624-33.
T
Tracy TE
,
Sohn PDongmin
,
S Minami S
,
Wang C
,
Min S-W
,
Li Y
,
Zhou Y
,
Le D
,
Lo I
,
Ponnusamy R
et al.
. 2016.
Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.
.
Neuron. 90(2):245-60.
W
Wahrle SE
,
Jiang H
,
Parsadanian M
,
Hartman RE
,
Bales KR
,
Paul SM
,
Holtzman DM
. 2005.
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
.
J Biol Chem. 280(52):43236-42.
X
Xu P
,
Chang JC
,
Zhou X
,
Wang W
,
Bamkole M
,
Wong E
,
Bettayeb K
,
Jiang L-L
,
Huang T
,
Luo W
et al.
. 2021.
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.
.
J Exp Med. 218(8)