Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 40 results
Author Title Type [ Year(Asc)]
Filters: Keyword is Humans and Author is Gan, Li  [Clear All Filters]
2012
Wang C, Sun B, Zhou Y, Grubb A, Gan L.  2012.  Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.. J Biol Chem. 287(47):39834-41.
Martens LHerl, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min S-W, Gan L, Finkbeiner S, Huang EJ et al..  2012.  Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.. J Clin Invest. 122(11):3955-9.
2011
Cho S-H, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L.  2011.  CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.. J Biol Chem. 286(37):32713-22.
Sun B, Gan L.  2011.  Manipulation of gene expression in the central nervous system with lentiviral vectors.. Methods Mol Biol. 670:155-68.
Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ, Chen J.  2011.  Protective effects and mechanisms of sirtuins in the nervous system.. Prog Neurobiol. 95(3):373-95.
2010
Min S-W, Cho S-H, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C et al..  2010.  Acetylation of tau inhibits its degradation and contributes to tauopathy.. Neuron. 67(6):953-66.
2009
Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L.  2009.  Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.. Cell Stem Cell. 5(6):624-33.
2008
Gan L, Mucke L.  2008.  Paths of convergence: sirtuins in aging and neurodegeneration.. Neuron. 58(1):10-4.
Sanchez-Mejia RO, Newman JW, Toh S, Yu G-Q, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L et al..  2008.  Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.. Nat Neurosci. 11(11):1311-8.
2007
Gan L.  2007.  Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.. Drug News Perspect. 20(4):233-9.
2006
Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L et al..  2006.  Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.. Neuron. 51(6):703-14.
2005
Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CAA, Whim MD, Yang B.  2005.  Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.. Hear Res. 206(1-2):133-45.
Chen J, Zhou Y, Mueller-Steiner S, Chen L-F, Kwon H, Yi S, Mucke L, Gan L.  2005.  SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.. J Biol Chem. 280(48):40364-74.
2004
Esposito L, Gan L, Yu G-Q, Essrich C, Mucke L.  2004.  Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.. J Neurochem. 91(6):1260-74.
Gresch O, Engel FB, Nesic D, Tran TThai, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S et al..  2004.  New non-viral method for gene transfer into primary cells.. Methods. 33(2):151-63.