Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 166 results

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Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ, Chen J. 2011. Protective effects and mechanisms of sirtuins in the nervous system.. Prog Neurobiol. 95(3):373-95.

Bosco DA, LaVoie MJ, Petsko GA, Ringe D. 2011. Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.. Cold Spring Harb Perspect Biol. 3(10):a007500.

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Lim H, He D, Qiu Y, Krawczuk P, Sun X, Xie L. 2019. Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology.. PLoS Comput Biol. 15(6):e1006619.

Birket MJ, Orr AL, Gerencser AA, Madden DT, Vitelli C, Swistowski A, Brand MD, Zeng X. 2011. A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells.. J Cell Sci. 124(Pt 3):348-58.

Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CAA, Whim MD, Yang B. 2005. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.. Hear Res. 206(1-2):133-45.

Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P et al.. 2011. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.. Nature. 469(7328):47-52.

Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL. 2013. The role of mitochondrial function and cellular bioenergetics in ageing and disease.. Br J Dermatol. 169 Suppl 2:1-8.

Benharouga M, Sharma M, So J, Haardt M, Drzymala L, Popov M, Schwapach B, Grinstein S, Du K, Lukacs GL. 2003. The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia.. J Biol Chem. 278(24):22079-89.

Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P et al.. 2007. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.. Proc Natl Acad Sci U S A. 104(22):9511-6.

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Siemers ER, Friedrich S, Dean RA, Gonzales CR, Farlow MR, Paul SM, DeMattos RB. 2010. Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.. Clin Neuropharmacol. 33(2):67-73.

Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PDongmin, Ludwig C, Meyer-Franke A et al.. 2017. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.. Stem Cell Reports. 9(4):1221-1233.

Shim J-H, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA et al.. 2013. Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.. J Clin Invest. 123(9):4010-22.

Cho S-H, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PDongmin, Lo I, Minami S et al.. 2015. SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.. J Neurosci. 35(2):807-18.

Chen J, Zhou Y, Mueller-Steiner S, Chen L-F, Kwon H, Yi S, Mucke L, Gan L. 2005. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.. J Biol Chem. 280(48):40364-74.

Liu Q, Lee B, Xie L. 2022. Small molecule modulation of microbiota: a systems pharmacology perspective.. BMC Bioinformatics. 23(Suppl 3):403.

Hamill CE, Goldshmidt A, Nicole O, McKeon RJ, Brat DJ, Traynelis SF. 2005. Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery.. Clin Neurosurg. 52:29-44.

Auclair JR, Boggio KJ, Petsko GA, Ringe D, Agar JN. 2010. Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis.. Proc Natl Acad Sci U S A. 107(50):21394-9.

Lai CF, Gong SC, Esteban M. 1990. Structural and functional properties of the 14-kDa envelope protein of vaccinia virus synthesized in Escherichia coli.. J Biol Chem. 265(36):22174-80.

Das C, Hoang QQ, Kreinbring CA, Luchansky SJ, Meray RK, Ray SS, Lansbury PT, Ringe D, Petsko GA. 2006. Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.. Proc Natl Acad Sci U S A. 103(12):4675-80.

Lieberman RL, Wustman BA, Huertas P, Powe AC, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA. 2007. Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.. Nat Chem Biol. 3(2):101-7.

Mullasseril P, Hansen KB, Vance KM, Ogden KK, Yuan H, Kurtkaya NL, Santangelo R, Orr AG, Le P, Vellano KM et al.. 2010. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.. Nat Commun. 1:90.

Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RLS et al.. 2015. Suppressors of superoxide production from mitochondrial complex III.. Nat Chem Biol. 11(11):834-6.

Burré J. 2015. The Synaptic Function of α-Synuclein.. J Parkinsons Dis. 5(4):699-713.

Burré J, Volknandt W. 2007. The synaptic vesicle proteome.. J Neurochem. 101(6):1448-62.

Bacaj T, Wu D, Burré J, Malenka RC, Liu X, Südhof TC. 2015. Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.. PLoS Biol. 13(10):e1002267.