Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 398 results
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Birket MJ, Orr AL, Gerencser AA, Madden DT, Vitelli C, Swistowski A, Brand MD, Zeng X.  2011.  A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells.. J Cell Sci. 124(Pt 3):348-58.
Orr AL, Quinlan CL, Perevoshchikova IV, Brand MD.  2012.  A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase.. J Biol Chem. 287(51):42921-35.
Gong S, Nussenzweig MC.  1996.  Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.. Science. 272(5260):411-4.
Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CAA, Whim MD, Yang B.  2005.  Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.. Hear Res. 206(1-2):133-45.
Oliveros G, Wallace CH, Chaudry O, Liu Q, Qiu Y, Xie L, Rockwell P, Figueiredo-Pereira ME, Serrano PA.  2023.  Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation.. Brain. 146(3):898-911.
Burré J, Edwards RH, Halliday G, Lang AE, Lashuel HA, Melki R, Murayama S, Outeiro TF, Papa SM, Stefanis L et al..  2024.  Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis.. Mov Disord. 39(10):1663-1678.
Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P et al..  2011.  Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.. Nature. 469(7328):47-52.
Parmar MS, Jaumotte JD, Wyrostek SL, Zigmond MJ, Cavanaugh JE.  2014.  The role of ERK1, 2, and 5 in dopamine neuron survival during aging.. Neurobiol Aging. 35(3):669-79.
Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL.  2013.  The role of mitochondrial function and cellular bioenergetics in ageing and disease.. Br J Dermatol. 169 Suppl 2:1-8.
Benharouga M, Sharma M, So J, Haardt M, Drzymala L, Popov M, Schwapach B, Grinstein S, Du K, Lukacs GL.  2003.  The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia.. J Biol Chem. 278(24):22079-89.
Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P et al..  2007.  Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.. Proc Natl Acad Sci U S A. 104(22):9511-6.
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Siemers ER, Friedrich S, Dean RA, Gonzales CR, Farlow MR, Paul SM, DeMattos RB.  2010.  Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.. Clin Neuropharmacol. 33(2):67-73.
Liao Z, Xie L, Mamitsuka H, Zhu S.  2023.  Sc2Mol: a scaffold-based two-step molecule generator with variational autoencoder and transformer.. Bioinformatics. 39(1)
Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PDongmin, Ludwig C, Meyer-Franke A et al..  2017.  Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.. Stem Cell Reports. 9(4):1221-1233.
Shim J-H, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA et al..  2013.  Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.. J Clin Invest. 123(9):4010-22.
S Minami S, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T et al..  2012.  Selective targeting of microglia by quantum dots.. J Neuroinflammation. 9:22.
Lopez-Lee C, Kodama L, Fan L, Wong MYing, Foxe NR, Jiaz L, Yu F, Ye P, Zhu J, Norman K et al..  2023.  Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging.. bioRxiv.
Lopez-Lee C, Kodama L, Gan L.  2021.  Sex Differences in Neurodegeneration: The Role of the Immune System in Humans.. Biol Psychiatry.
Orr AL, Huang S, Roberts MA, Reed JC, Li S, Li X-J.  2008.  Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.. J Biol Chem. 283(23):16027-36.
Xiao L, Zhang C, Li X, Gong S, Hu R, Balasubramanian R, W WFCrowley, Hastings MH, Zhou Q-Y.  2014.  Signaling role of prokineticin 2 on the estrous cycle of female mice.. PLoS One. 9(3):e90860.
Gong SC, Lai CF, Dallo S, Esteban M.  1989.  A single point mutation of Ala-25 to Asp in the 14,000-Mr envelope protein of vaccinia virus induces a size change that leads to the small plaque size phenotype of the virus.. J Virol. 63(11):4507-14.
Gupta I, Collier PG, Haase B, Mahfouz A, Joglekar A, Floyd T, Koopmans F, Barres B, Smit AB, Sloan SA et al..  2018.  Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells.. Nat Biotechnol.
Hardwick SA, Hu W, Joglekar A, Fan L, Collier PG, Foord C, Balacco J, Lanjewar S, Sampson MMcGuirk, Koopmans F et al..  2022.  Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue.. Nat Biotechnol.
Min S-W, Sohn PDongmin, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok S-A, Gestwicki JE, Gan L.  2018.  SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.. J Neurosci. 38(15):3680-3688.
Cho S-H, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PDongmin, Lo I, Minami S et al..  2015.  SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.. J Neurosci. 35(2):807-18.