Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

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Wang Z, Lipshutz A, de la Torre CMartínez, Trzeciak AJ, Liu Z-L, Miranda IC, Lazarov T, Codo AC, Romero-Pichardo JE, Nair A et al.. 2025. Early life high fructose impairs microglial phagocytosis and neurodevelopment.. Nature. 644(8077):759-768.

Wang LY, Gan L, Forsythe ID, Kaczmarek LK. 1998. Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones.. J Physiol. 509 ( Pt 1):183-94.

Wang C, Sun B, Zhou Y, Grubb A, Gan L. 2012. Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.. J Biol Chem. 287(47):39834-41.

Wang C, Telpoukhovskaia MA, Bahr BA, Chen X, Gan L. 2018. Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.. Curr Opin Neurobiol. 48:52-58.

Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LHerl, Seeley WW et al.. 2014. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.. J Exp Med. 211(10):1937-45.

Ward ME, Chen R, Huang H-Y, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P et al.. 2017. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.. Sci Transl Med. 9(385)

Wes PD, Sayed FA, Bard F, Gan L. 2016. Targeting microglia for the treatment of Alzheimer's Disease.. Glia. 64(10):1710-32.

A Willsey J, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA et al.. 2018. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.. Cell. 174(3):505-520.

Witten IB, Steinberg EE, Lee SYeun, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C et al.. 2011. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.. Neuron. 72(5):721-33.

Wong H-S, Monternier P-A, Orr AL, Brand MD. 2018. Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria.. Methods Mol Biol. 1782:287-299.

Wong MYing, Lewis M, Doherty JJ, Shi Y, Cashikar AG, Amelianchik A, Tymchuk S, Sullivan PM, Qian M, Covey DF et al.. 2020. 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.. J Neuroinflammation. 17(1):192.

Wu Y, Liu Q, Xie L. 2023. Hierarchical multi-omics data integration and modeling predict cell-specific chemical proteomics and drug responses.. Cell Rep Methods. 3(4):100452.

Wu Y, Liu Q, Qiu Y, Xie L. 2022. Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer's disease drug repurposing.. PLoS Comput Biol. 18(8):e1010367.

Wu X, Gong S, Roy-Burman P, Lee P, Culig Z. 2013. Current mouse and cell models in prostate cancer research.. Endocr Relat Cancer. 20(4):R155-70.

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Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al.. 2022. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.

Xiao L, Zhang C, Li X, Gong S, Hu R, Balasubramanian R, W WFCrowley, Hastings MH, Zhou Q-Y. 2014. Signaling role of prokineticin 2 on the estrous cycle of female mice.. PLoS One. 9(3):e90860.

Xie L, Xie L. 2023. Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning.. PLoS Comput Biol. 19(8):e1010974.

Xie L, Xie L. 2019. Pathway-Centric Structure-Based Multi-Target Compound Screening for Anti-Virulence Drug Repurposing.. Int J Mol Sci. 20(14)

Xie YXue, Naseri NN, Fels J, Kharel P, Na Y, Lane D, Burré J, Sharma M. 2022. Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.. Nat Commun. 13(1):4918.

Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L. 1999. Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.. Proc Natl Acad Sci U S A. 96(13):7547-52.

Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang L-L, Huang T, Luo W et al.. 2021. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.. J Exp Med. 218(8)

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Yan Y, Wang X, Chaput D, Shin M-K, Koh Y, Gan L, Pieper AA, Woo J-AA, Kang DE. 2022. X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.. Cell. 185(21):3913-3930.e19.

X Yang W, Gong S. 2005. An overview on the generation of BAC transgenic mice for neuroscience research.. Curr Protoc Neurosci. Chapter 5:Unit5.20.

Yang X, Wen J, Yang H, Jones IR, Zhu X, Liu W, Li B, Clelland CD, Luo W, Wong MYing et al.. 2023. Functional characterization of Alzheimer's disease genetic variants in microglia.. Nat Genet. 55(10):1735-1744.

Yang Z, Jiang H, Chaichanasakul T, Chachainasakul T, Gong S, Yang XWilliam, Heintz N, Lin S. 2006. Modified bacterial artificial chromosomes for zebrafish transgenesis.. Methods. 39(3):183-8.