Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 442 results
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Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V et al..  2020.  A Pentacyclic Triterpene from Targets γ-Secretase.. ACS Chem Neurosci. 11(18):2827-2835.
Luo W-jie, Wang H, Li H, Kim BS, Shah S, Lee H-J, Thinakaran G, Kim T-W, Yu G, Xu H.  2003.  PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.. J Biol Chem. 278(10):7850-4.
Xie L, Xie L.  2019.  Pathway-Centric Structure-Based Multi-Target Compound Screening for Anti-Virulence Drug Repurposing.. Int J Mol Sci. 20(14)
Gan L, Mucke L.  2008.  Paths of convergence: sirtuins in aging and neurodegeneration.. Neuron. 58(1):10-4.
Gu X, Li C, Wei W, Lo V, Gong S, Li S-H, Iwasato T, Itohara S, Li X-J, Mody I et al..  2005.  Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.. Neuron. 46(3):433-44.
Sohn PDongmin, Huang CTzu-Ling, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok S-A, Freilich R et al..  2019.  Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.. Neuron.
Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR.  2004.  The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.. Proc Natl Acad Sci U S A. 101(24):9103-8.
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Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL.  2006.  The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein.. J Mol Biol. 356(4):1036-48.
X Yang W, Gong S.  2005.  An overview on the generation of BAC transgenic mice for neuroscience research.. Curr Protoc Neurosci. Chapter 5:Unit5.20.
Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM.  2009.  Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.. Neuron. 64(5):632-44.
Clelland CDudley, Fan L, Saloner R, Etchegaray JIker, Altobelli CRichard, Salomonsson S, Maltos AM, Sachdev A, Zhu J, Lee S-I et al..  2025.  Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.. Commun Biol. 8(1):971.
Petsko GA.  2013.  Open questions: Zombie projects, translational research, and the real secret of the inside of the cell.. BMC Biol. 11:97.
Heintz N, Gong S.  2020.  One-Step Bacterial Artificial Chromosome (BAC) Modification: Transformation of the BAC Host with the RecA Vector.. Cold Spring Harb Protoc. 2020(7):098129.
Heintz N, Gong S.  2020.  One-Step Bacterial Artificial Chromosome (BAC) Modification: Transfer of the Reporter Vector into BAC/RecA Cells and Selection of Co-Integrates.. Cold Spring Harb Protoc. 2020(7):098137.
Heintz N, Gong S.  2020.  One-Step Bacterial Artificial Chromosome (BAC) Modification: Preparation of Plasmids.. Cold Spring Harb Protoc. 2020(7):098095.
Heintz N, Gong S.  2020.  One-Step Bacterial Artificial Chromosome (BAC) Modification: Preparation of the A Homology Arm (A-Box).. Cold Spring Harb Protoc. 2020(7):098103.
Heintz N, Gong S.  2020.  One-Step Bacterial Artificial Chromosome (BAC) Modification: Cloning of the A Homology Arm into Reporter-Shuttle Vector.. Cold Spring Harb Protoc. 2020(7):098111.
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Orr AL, Li S, Wang C-E, Li H, Wang J, Rong J, Xu X, Mastroberardino PGiorgio, J Greenamyre T, Li X-J.  2008.  N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.. J Neurosci. 28(11):2783-92.
Orr AL, Ashok D, Sarantos MR, Ng R, Shi T, Gerencser AA, Hughes RE, Brand MD.  2014.  Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.. PLoS One. 9(2):e89938.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al..  2024.  Novel avenues of tau research.. Alzheimers Dement.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al..  2022.  Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.
Zhou Y, Su Y, Li B, Liu F, Ryder JW, Wu X, Gonzalez-DeWhitt PA, Gelfanova V, Hale JE, May PC et al..  2003.  Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.. Science. 302(5648):1215-7.
Burré J, Wittig I, Schägger H.  2009.  Non-classical 2-D electrophoresis.. Methods Mol Biol. 564:33-57.
Pranski E, Van Sanford CD, Dalal N, Orr AL, Karmali D, Cooper DS, Gearing M, Lah JJ, Levey AI, Betarbet R.  2013.  NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease.. Neurosci Lett. 547:16-20.
Bales KR, Du Y, Dodel RC, Yan GM, Hamilton-Byrd E, Paul SM.  1998.  The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation.. Brain Res Mol Brain Res. 57(1):63-72.