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2
Fargo KN
,
Aisen P
,
Albert M
,
Au R
,
Corrada MM
,
DeKosky S
,
Drachman D
,
Fillit H
,
Gitlin L
,
Haas M
et al.
. 2014.
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
.
Alzheimers Dement. 10(5 Suppl):S430-52.
Wong MYing
,
Lewis M
,
Doherty JJ
,
Shi Y
,
Cashikar AG
,
Amelianchik A
,
Tymchuk S
,
Sullivan PM
,
Qian M
,
Covey DF
et al.
. 2020.
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.
.
J Neuroinflammation. 17(1):192.
3
Lai CF
,
Gong SC
,
Esteban M
. 1991.
The 32-kilodalton envelope protein of vaccinia virus synthesized in Escherichia coli binds with specificity to cell surfaces.
.
J Virol. 65(1):499-504.
8
Sha SJ
,
Miller ZA
,
Min S-W
,
Zhou Y
,
Brown J
,
Mitic LL
,
Karydas A
,
Koestler M
,
Tsai R
,
Corbetta-Rastelli C
et al.
. 2017.
An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from gene mutations.
.
Alzheimers Dement (N Y). 3(4):507-512.
A
Wang C-E
,
Tydlacka S
,
Orr AL
,
Yang S-H
,
Graham RK
,
Hayden MR
,
Li S
,
Chan AWS
,
Li X-J
. 2008.
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.
.
Hum Mol Genet. 17(17):2738-51.
Sohn PDongmin
,
Tracy TE
,
Son H-I
,
Zhou Y
,
Leite REP
,
Miller BL
,
Seeley WW
,
Grinberg LT
,
Gan L
. 2016.
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
.
Mol Neurodegener. 11(1):47.
Tracy TE
,
Gan L
. 2017.
Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy.
.
Bioessays. 39(4)
Caballero B
,
Bourdenx M
,
Luengo E
,
Diaz A
,
Sohn PDongmin
,
Chen X
,
Wang C
,
Juste YR
,
Wegmann S
,
Patel B
et al.
. 2021.
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.
.
Nat Commun. 12(1):2238.
Tracy TE
,
Sohn PDongmin
,
S Minami S
,
Wang C
,
Min S-W
,
Li Y
,
Zhou Y
,
Le D
,
Lo I
,
Ponnusamy R
et al.
. 2016.
Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.
.
Neuron. 90(2):245-60.
Min S-W
,
Cho S-H
,
Zhou Y
,
Schroeder S
,
Haroutunian V
,
Seeley WW
,
Huang EJ
,
Shen Y
,
Masliah E
,
Mukherjee C
et al.
. 2010.
Acetylation of tau inhibits its degradation and contributes to tauopathy.
.
Neuron. 67(6):953-66.
Wang LY
,
Gan L
,
Perney TM
,
Schwartz I
,
Kaczmarek LK
. 1998.
Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion.
.
Proc Natl Acad Sci U S A. 95(4):1882-7.
Nicole O
,
Goldshmidt A
,
Hamill CE
,
Sorensen SD
,
Sastre A
,
Lyuboslavsky P
,
Hepler JR
,
McKeon RJ
,
Traynelis SF
. 2005.
Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.
.
J Neurosci. 25(17):4319-29.
Orr AG
,
Orr AL
,
Li X-J
,
Gross RE
,
Traynelis SF
. 2009.
Adenosine A(2A) receptor mediates microglial process retraction.
.
Nat Neurosci. 12(7):872-8.
Sayed FA
,
Kodama L
,
Fan L
,
Carling GK
,
Udeochu JC
,
Le D
,
Li Q
,
Zhou L
,
Wong MYing
,
Horowitz R
et al.
. 2021.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
.
Sci Transl Med. 13(622):eabe3947.
Naseri NN
,
Ergel B
,
Kharel P
,
Na Y
,
Huang Q
,
Huang R
,
Dolzhanskaya N
,
Burré J
,
Velinov MT
,
Sharma M
. 2020.
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
.
Nat Struct Mol Biol. 27(2):192-201.
Burré J
,
Sharma M
,
Tsetsenis T
,
Buchman V
,
Etherton MR
,
Südhof TC
. 2010.
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
.
Science. 329(5999):1663-7.
Burré J
,
Beckhaus T
,
Schägger H
,
Corvey C
,
Hofmann S
,
Karas M
,
Zimmermann H
,
Volknandt W
. 2006.
Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques.
.
Proteomics. 6(23):6250-62.
Brendza RP
,
Bacskai BJ
,
Cirrito JR
,
Simmons KA
,
Skoch JM
,
Klunk WE
,
Mathis CA
,
Bales KR
,
Paul SM
,
Hyman BT
et al.
. 2005.
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
.
J Clin Invest. 115(2):428-33.
Mueller-Steiner S
,
Zhou Y
,
Arai H
,
Roberson ED
,
Sun B
,
Chen J
,
Wang X
,
Yu G
,
Esposito L
,
Mucke L
et al.
. 2006.
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
.
Neuron. 51(6):703-14.
DeMattos RB
,
Cirrito JR
,
Parsadanian M
,
May PC
,
O'dell MA
,
Taylor JW
,
Harmony JAK
,
Aronow BJ
,
Bales KR
,
Paul SM
et al.
. 2004.
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.
.
Neuron. 41(2):193-202.
Shi Y
,
Yamada K
,
Liddelow SAntony
,
Smith ST
,
Zhao L
,
Luo W
,
Tsai RM
,
Spina S
,
Grinberg LT
,
Rojas JC
et al.
. 2017.
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
.
Nature. 549(7673):523-527.
Cao J
,
Gaamouch FEl
,
Meabon JS
,
Meeker KD
,
Zhu L
,
Zhong MB
,
Bendik J
,
Elder G
,
Jing P
,
Xia J
et al.
. 2017.
ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury.
.
Sci Rep. 7(1):11372.
Bales KR
,
Verina T
,
Cummins DJ
,
Du Y
,
Dodel RC
,
Saura J
,
Fishman CE
,
DeLong CA
,
Piccardo P
,
Petegnief V
et al.
. 1999.
Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.
.
Proc Natl Acad Sci U S A. 96(26):15233-8.
Holtzman DM
,
Bales KR
,
Tenkova T
,
Fagan AM
,
Parsadanian M
,
Sartorius LJ
,
Mackey B
,
Olney J
,
McKeel D
,
Wozniak D
et al.
. 2000.
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.
.
Proc Natl Acad Sci U S A. 97(6):2892-7.
Koistinaho M
,
Lin S
,
Wu X
,
Esterman M
,
Koger D
,
Hanson J
,
Higgs R
,
Liu F
,
Malkani S
,
Bales KR
et al.
. 2004.
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.
.
Nat Med. 10(7):719-26.
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