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Found 376 results
Author
Title
[
Type
]
Year
Journal Article
Ward ME
,
Chen R
,
Huang H-Y
,
Ludwig C
,
Telpoukhovskaia M
,
Taubes A
,
Boudin H
,
Minami SS
,
Reichert M
,
Albrecht P
et al.
. 2017.
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
.
Sci Transl Med. 9(385)
Boselli M
,
Lee B-H
,
Robert J
,
Prado MA
,
Min S-W
,
Cheng C
,
M Silva C
,
Seong C
,
Elsasser S
,
Hatle KM
et al.
. 2017.
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
.
J Biol Chem. 292(47):19209-19225.
Orr AL
,
Ashok D
,
Sarantos MR
,
Shi T
,
Hughes RE
,
Brand MD
. 2013.
Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.
.
Free Radic Biol Med. 65:1047-1059.
Orr AG
,
Sharma A
,
Binder NB
,
Miller AH
,
Pearce BD
. 2010.
Interleukin-1 mediates long-term hippocampal dentate granule cell loss following postnatal viral infection.
.
J Mol Neurosci. 41(1):89-96.
Esposito L
,
Gan L
,
Yu G-Q
,
Essrich C
,
Mucke L
. 2004.
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
.
J Neurochem. 91(6):1260-74.
Zhao L
,
Gottesdiener AJ
,
Parmar M
,
Li M
,
Kaminsky SM
,
Chiuchiolo MJ
,
Sondhi D
,
Sullivan PM
,
Holtzman DM
,
Crystal RG
et al.
. 2016.
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
.
Neurobiol Aging. 44:159-72.
Orr AG
,
Lo I
,
Schumacher H
,
Ho K
,
Gill M
,
Guo W
,
Kim DH
,
Knox A
,
Saito T
,
Saido TC
et al.
. 2018.
Istradefylline reduces memory deficits in aging mice with amyloid pathology.
.
Neurobiol Dis. 110:29-36.
Kauwe G
,
Pareja-Navarro KA
,
Yao L
,
Chen JH
,
Wong I
,
Saloner R
,
Cifuentes H
,
Nana AL
,
Shah S
,
Li Y
et al.
. 2024.
KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
.
J Clin Invest. 134(3)
Kauwe G
,
Pareja-Navarro KA
,
Yao L
,
Chen JH
,
Wong I
,
Saloner R
,
Cifuentes H
,
Nana AL
,
Shah S
,
Li Y
et al.
. 2023.
KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
.
bioRxiv.
Huang Y
,
Shenoy S
,
Lu B
,
Liu W
,
Li C
. 2012.
Kinase signaling dysfunction in Parkinson's disease: a reverse genetic approach in Drosophila.
.
J Neurogenet. 26(2):158-67.
Bales KR
,
Verina T
,
Dodel RC
,
Du Y
,
Altstiel L
,
Bender M
,
Hyslop P
,
Johnstone EM
,
Little SP
,
Cummins DJ
et al.
. 1997.
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.
.
Nat Genet. 17(3):263-4.
Heintz N
,
Gong S
. 2019.
Large-Scale Preparation and Linearization of Bacterial Artificial Chromosome (BAC) DNA.
.
Cold Spring Harb Protoc. 2019(11)
Bharadwaj PR
,
Verdile G
,
Barr RK
,
Gupta V
,
Steele JW
,
M Lachenmayer L
,
Yue Z
,
Ehrlich ME
,
Petsko G
,
Ju S
et al.
. 2012.
Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.
.
J Alzheimers Dis. 32(4):949-67.
Steele JW
,
Lachenmayer ML
,
Ju S
,
Stock A
,
Liken J
,
Kim SH
,
Delgado LM
,
Alfaro IE
,
Bernales S
,
Verdile G
et al.
. 2013.
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.
.
Mol Psychiatry. 18(8):889-97.
Steele JW
,
Ju S
,
Lachenmayer ML
,
Liken J
,
Stock A
,
Kim SH
,
Delgado LM
,
Alfaro IE
,
Bernales S
,
Verdile G
et al.
. 2013.
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.
.
Mol Psychiatry. 18(8):882-8.
Sanchez PE
,
Zhu L
,
Verret L
,
Vossel KA
,
Orr AG
,
Cirrito JR
,
Devidze N
,
Ho K
,
Yu G-Q
,
Palop JJ
et al.
. 2012.
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.
.
Proc Natl Acad Sci U S A. 109(42):E2895-903.
Liang Y
,
Lin S
,
Beyer TP
,
Zhang Y
,
Wu X
,
Bales KR
,
DeMattos RB
,
May PC
,
Li SDan
,
Jiang X-C
et al.
. 2004.
A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.
.
J Neurochem. 88(3):623-34.
Bhattacharjee A
,
Gan L
,
Kaczmarek LK
. 2002.
Localization of the Slack potassium channel in the rat central nervous system.
.
J Comp Neurol. 454(3):241-54.
Ray SD
,
Parmar M
,
Syed I
,
Rathod J
,
Zinkovsky D
,
Bulku E
,
Gigliotti J
,
Hackman RM
,
Stohs SJ
. 2008.
Long term exposure effect of a unique metabolic nutrition system containing a diverse group of phytochemicals on serum chemistry and genomic and non-genomic changes in the liver of female B6C3F1 mice.
.
Phytother Res. 22(4):458-71.
Orr AL
,
Rutaganira FU
,
de Roulet D
,
Huang EJ
,
Hertz NT
,
Shokat KM
,
Nakamura K
. 2017.
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
.
Neurochem Int. 109:106-116.
Pathak D
,
Berthet A
,
Bendor JT
,
Yu K
,
Sellnow RC
,
Orr AL
,
Nguyen MK
,
Edwards RH
,
Manfredsson FP
,
Nakamura K
. 2017.
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.
.
eNeuro. 4(2)
Xie YXue
,
Naseri NN
,
Fels J
,
Kharel P
,
Na Y
,
Lane D
,
Burré J
,
Sharma M
. 2022.
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.
.
Nat Commun. 13(1):4918.
Zhan L
,
Fan L
,
Kodama L
,
Sohn PDongmin
,
Wong MYing
,
Mousa GAlzaem
,
Zhou Y
,
Li Y
,
Gan L
. 2020.
A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain.
.
Elife. 9
Zhao L
,
Lin S
,
Bales KR
,
Gelfanova V
,
Koger D
,
DeLong C
,
Hale J
,
Liu F
,
Hunter JM
,
Paul SM
. 2009.
Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.
.
J Neurosci. 29(11):3603-12.
Paul SM
,
Doherty JJ
,
Robichaud AJ
,
Belfort GM
,
Chow BY
,
Hammond RS
,
Crawford DC
,
Linsenbardt AJ
,
Shu H-J
,
Izumi Y
et al.
. 2013.
The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.
.
J Neurosci. 33(44):17290-300.
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