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Found 17 results
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Südhof, Thomas C
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Journal Article
Burré J
,
Sharma M
,
Tsetsenis T
,
Buchman V
,
Etherton MR
,
Südhof TC
. 2010.
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
.
Science. 329(5999):1663-7.
Etherton MR
,
Tabuchi K
,
Sharma M
,
Ko J
,
Südhof TC
. 2011.
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
.
EMBO J. 30(14):2908-19.
Mukherjee K
,
Sharma M
,
Urlaub H
,
Bourenkov GP
,
Jahn R
,
Südhof TC
,
Wahl MC
. 2008.
CASK Functions as a Mg2+-independent neurexin kinase.
.
Cell. 133(2):328-39.
Burré J
,
Sharma M
,
Südhof TC
. 2018.
Cell Biology and Pathophysiology of α-Synuclein.
.
Cold Spring Harb Perspect Med. 8(3)
Sharma M
,
Burré J
,
Bronk P
,
Zhang Y
,
Xu W
,
Südhof TC
. 2012.
CSPα knockout causes neurodegeneration by impairing SNAP-25 function.
.
EMBO J. 31(4):829-41.
Sharma M
,
Burré J
,
Südhof TC
. 2011.
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
.
Nat Cell Biol. 13(1):30-9.
Burré J
,
Sharma M
,
Südhof TC
. 2015.
Definition of a molecular pathway mediating α-synuclein neurotoxicity.
.
J Neurosci. 35(13):5221-32.
Mukherjee K
,
Sharma M
,
Jahn R
,
Wahl MC
,
Südhof TC
. 2010.
Evolution of CASK into a Mg2+-sensitive kinase.
.
Sci Signal. 3(119):ra33.
Acuna C
,
Guo Q
,
Burré J
,
Sharma M
,
Sun J
,
Südhof TC
. 2014.
Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity.
.
Neuron. 82(5):1088-100.
Diao J
,
Burré J
,
Vivona S
,
Cipriano DJ
,
Sharma M
,
Kyoung M
,
Südhof TC
,
Brunger AT
. 2013.
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.
.
Elife. 2:e00592.
Lai Y
,
Zhao C
,
Tian Z
,
Wang C
,
Fan J
,
Hu X
,
Tu J
,
Li T
,
Leitz J
,
Pfuetzner RA
et al.
. 2023.
Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.
.
Proc Natl Acad Sci U S A. 120(44):e2310174120.
Burré J
,
Vivona S
,
Diao J
,
Sharma M
,
Brunger AT
,
Südhof TC
. 2013.
Properties of native brain α-synuclein.
.
Nature. 498(7453):E4-6;discussionE6-7.
Sharma M
,
Burré J
,
Südhof TC
. 2012.
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
.
Sci Transl Med. 4(147):147ra113.
Lee SHun
,
Sharma M
,
Südhof TC
,
Shen J
. 2014.
Synaptic function of nicastrin in hippocampal neurons.
.
Proc Natl Acad Sci U S A. 111(24):8973-8.
Bacaj T
,
Wu D
,
Burré J
,
Malenka RC
,
Liu X
,
Südhof TC
. 2015.
Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.
.
PLoS Biol. 13(10):e1002267.
Burré J
,
Sharma M
,
Südhof TC
. 2012.
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities.
.
J Neurosci. 32(43):15227-42.
Burré J
,
Sharma M
,
Südhof TC
. 2014.
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
.
Proc Natl Acad Sci U S A. 111(40):E4274-83.