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Found 15 results
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Mucke, Lennart
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Journal Article
Das M
,
Mao W
,
Voskobiynyk Y
,
Necula D
,
Lew I
,
Petersen C
,
Zahn A
,
Yu G-Q
,
Yu X
,
Smith N
et al.
. 2023.
Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.
.
Neurobiol Dis. 186:106263.
Mueller-Steiner S
,
Zhou Y
,
Arai H
,
Roberson ED
,
Sun B
,
Chen J
,
Wang X
,
Yu G
,
Esposito L
,
Mucke L
et al.
. 2006.
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
.
Neuron. 51(6):703-14.
Orr AG
,
Hsiao EC
,
Wang MM
,
Ho K
,
Kim DH
,
Wang X
,
Guo W
,
Kang J
,
Yu G-Q
,
Adame A
et al.
. 2015.
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
.
Nat Neurosci. 18(3):423-34.
Sun B
,
Halabisky B
,
Zhou Y
,
Palop JJ
,
Yu G
,
Mucke L
,
Gan L
. 2009.
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.
.
Cell Stem Cell. 5(6):624-33.
Esposito L
,
Gan L
,
Yu G-Q
,
Essrich C
,
Mucke L
. 2004.
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
.
J Neurochem. 91(6):1260-74.
Orr AG
,
Lo I
,
Schumacher H
,
Ho K
,
Gill M
,
Guo W
,
Kim DH
,
Knox A
,
Saito T
,
Saido TC
et al.
. 2018.
Istradefylline reduces memory deficits in aging mice with amyloid pathology.
.
Neurobiol Dis. 110:29-36.
Sanchez PE
,
Zhu L
,
Verret L
,
Vossel KA
,
Orr AG
,
Cirrito JR
,
Devidze N
,
Ho K
,
Yu G-Q
,
Palop JJ
et al.
. 2012.
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.
.
Proc Natl Acad Sci U S A. 109(42):E2895-903.
Martinez-Losa M
,
Tracy TE
,
Ma K
,
Verret L
,
Clemente-Perez A
,
Khan AS
,
Cobos I
,
Ho K
,
Gan L
,
Mucke L
et al.
. 2018.
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.
.
Neuron. 98(1):75-89.e5.
Gan L
,
Mucke L
. 2008.
Paths of convergence: sirtuins in aging and neurodegeneration.
.
Neuron. 58(1):10-4.
Sanchez-Mejia RO
,
Newman JW
,
Toh S
,
Yu G-Q
,
Zhou Y
,
Halabisky B
,
Cissé M
,
Scearce-Levie K
,
Cheng IH
,
Gan L
et al.
. 2008.
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.
.
Nat Neurosci. 11(11):1311-8.
S Minami S
,
Min S-W
,
Krabbe G
,
Wang C
,
Zhou Y
,
Asgarov R
,
Li Y
,
Martens LH
,
Elia LP
,
Ward ME
et al.
. 2014.
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
.
Nat Med. 20(10):1157-64.
A Willsey J
,
Morris MT
,
Wang S
,
Willsey HR
,
Sun N
,
Teerikorpi N
,
Baum TB
,
Cagney G
,
Bender KJ
,
Desai TA
et al.
. 2018.
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
.
Cell. 174(3):505-520.
Cissé M
,
Halabisky B
,
Harris J
,
Devidze N
,
Dubal DB
,
Sun B
,
Orr A
,
Lotz G
,
Kim DH
,
Hamto P
et al.
. 2011.
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
.
Nature. 469(7328):47-52.
S Minami S
,
Sun B
,
Popat K
,
Kauppinen T
,
Pleiss M
,
Zhou Y
,
Ward ME
,
Floreancig P
,
Mucke L
,
Desai T
et al.
. 2012.
Selective targeting of microglia by quantum dots.
.
J Neuroinflammation. 9:22.
Chen J
,
Zhou Y
,
Mueller-Steiner S
,
Chen L-F
,
Kwon H
,
Yi S
,
Mucke L
,
Gan L
. 2005.
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
.
J Biol Chem. 280(48):40364-74.