Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

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Journal Article

Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M et al.. 2019. Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.. Nat Genet. 51(8):1252-1262.

Huang Y, Liu B, Sinha SC, Amin S, Gan L. 2023. Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders.. Mol Neurodegener. 18(1):79.

Lopez-Lee C, Torres ERuth S, Carling G, Gan L. 2024. Mechanisms of sex differences in Alzheimer's disease.. Neuron.

Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC et al.. 2019. Microglial microRNAs mediate sex-specific responses to tau pathology.. Nat Neurosci.

Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al.. 2022. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.

Krabbe G, S Minami S, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC et al.. 2017. Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.. Proc Natl Acad Sci U S A. 114(19):5029-5034.

Snyder HM, Carare RO, DeKosky ST, de Leon MJ, Dykxhoorn D, Gan L, Gardner R, Hinds SR, Jaffee M, Lamb BT et al.. 2018. Military-related risk factors for dementia.. Alzheimers Dement. 14(12):1651-1662.

Kuo S-H, Tasset I, Cheng MM, Diaz A, Pan M-K, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P et al.. 2022. Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.. Sci Adv. 8(6):eabm6393.

Zhu PK, W Zheng S, Zhang P, Jing M, Borden PM, Ali F, Guo K, Feng J, Marvin JS, Wang Y et al.. 2020. Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors.. Nano Lett. 20(6):4073-4083.

Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L et al.. 2018. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.. Neuron. 98(1):75-89.e5.

Ford BD, Liu Y, Mann MAnne, Krauss R, Phillips K, Gan L, Fischbach GD. 2003. Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes.. Biochem Biophys Res Commun. 308(1):23-8.

Kong W, Frouard J, Xie G, Corley MJ, Helmy E, Zhang G, Schwarzer R, Montano M, Sohn P, Roan NR et al.. 2024. Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids.. PNAS Nexus. 3(5):pgae179.

Amin S, Carling G, Gan L. 2021. New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.. Curr Opin Neurobiol. 72:131-139.

Gresch O, Engel FB, Nesic D, Tran TThai, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S et al.. 2004. New non-viral method for gene transfer into primary cells.. Methods. 33(2):151-63.

Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al.. 2024. Novel avenues of tau research.. Alzheimers Dement.

Sohn PDongmin, Huang CTzu-Ling, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok S-A, Freilich R et al.. 2019. Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.. Neuron.

Gan L, Mucke L. 2008. Paths of convergence: sirtuins in aging and neurodegeneration.. Neuron. 58(1):10-4.

Sanchez-Mejia RO, Newman JW, Toh S, Yu G-Q, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L et al.. 2008. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.. Nat Neurosci. 11(11):1311-8.

Kauppinen TM, Gan L, Swanson RA. 2013. Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.. Biochim Biophys Acta. 1833(8):1985-91.

Kauppinen TM, Suh SWon, Higashi Y, Berman AE, Escartin C, Won SJoon, Wang C, Cho S-H, Gan L, Swanson RA. 2011. Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.. J Neuroinflammation. 8:152.

Lin L-C, Nana AL, Hepker M, Hwang J-HLee, Gaus SE, Spina S, Cosme CG, Gan L, Grinberg LT, Geschwind DH et al.. 2019. Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.. Acta Neuropathol Commun. 7(1):159.

Martens LHerl, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min S-W, Gan L, Finkbeiner S, Huang EJ et al.. 2012. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.. J Clin Invest. 122(11):3955-9.

S Minami S, Min S-W, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME et al.. 2014. Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.. Nat Med. 20(10):1157-64.

Chen X, Li Y, Wang C, Tang Y, Mok S-A, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL et al.. 2020. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.. Mol Neurodegener. 15(1):2.

Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ, Chen J. 2011. Protective effects and mechanisms of sirtuins in the nervous system.. Prog Neurobiol. 95(3):373-95.