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L
Lim H
,
He D
,
Qiu Y
,
Krawczuk P
,
Sun X
,
Xie L
. 2019.
Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology.
.
PLoS Comput Biol. 15(6):e1006619.
Limbad C
,
Oron TRonnen
,
Alimirah F
,
Davalos AR
,
Tracy TE
,
Gan L
,
Desprez P-Y
,
Campisi J
. 2020.
Astrocyte senescence promotes glutamate toxicity in cortical neurons.
.
PLoS One. 15(1):e0227887.
Lin L-C
,
Nana AL
,
Hepker M
,
Hwang J-HLee
,
Gaus SE
,
Spina S
,
Cosme CG
,
Gan L
,
Grinberg LT
,
Geschwind DH
et al.
. 2019.
Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.
.
Acta Neuropathol Commun. 7(1):159.
Linsenbardt AJ
,
Taylor A
,
Emnett CM
,
Doherty JJ
,
Krishnan K
,
Covey DF
,
Paul SM
,
Zorumski CF
,
Mennerick S
. 2014.
Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.
.
Neuropharmacology. 85:232-42.
Liu Q
,
Lee B
,
Xie L
. 2022.
Small molecule modulation of microbiota: a systems pharmacology perspective.
.
BMC Bioinformatics. 23(Suppl 3):403.
Liu Y
,
Lim H
,
Xie L
. 2022.
Exploration of chemical space with partial labeled noisy student self-training and self-supervised graph embedding.
.
BMC Bioinformatics. 23(Suppl 3):158.
Liu CFeng
,
Liu D
,
Momb J
,
Thomas PW
,
Lajoie A
,
Petsko GA
,
Fast W
,
Ringe D
. 2013.
A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.
.
Biochemistry. 52(9):1603-10.
Liu Q
,
He D
,
Xie L
. 2019.
Prediction of off-target specificity and cell-specific fitness of CRISPR-Cas System using attention boosted deep learning and network-based gene feature.
.
PLoS Comput Biol. 15(10):e1007480.
Liu W
,
Acín-Peréz R
,
Geghman KD
,
Manfredi G
,
Lu B
,
Li C
. 2011.
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.
.
Proc Natl Acad Sci U S A. 108(31):12920-4.
Lopez-Lee C
,
Kodama L
,
Gan L
. 2021.
Sex Differences in Neurodegeneration: The Role of the Immune System in Humans.
.
Biol Psychiatry.
Lopez-Lee C
,
Kodama L
,
Fan L
,
Wong MYing
,
Foxe NR
,
Jiaz L
,
Yu F
,
Ye P
,
Zhu J
,
Norman K
et al.
. 2023.
Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging.
.
bioRxiv.
Lopez-Lee C
,
Torres ERuth S
,
Carling G
,
Gan L
. 2024.
Mechanisms of sex differences in Alzheimer's disease.
.
Neuron.
Luo W
,
Ip FCF
,
Fu G
,
Cheung K
,
Tian Y
,
Hu Y
,
Sinha A
,
Cheng EYL
,
Wu X
,
Bustos V
et al.
. 2020.
A Pentacyclic Triterpene from Targets γ-Secretase.
.
ACS Chem Neurosci. 11(18):2827-2835.
Luo W
,
Qu W
,
Gan L
. 2023.
The AD odyssey 2023: Tales of single cell.
.
Cell. 186(20):4257-4259.
Luo W-jie
,
Wang H
,
Li H
,
Kim BS
,
Shah S
,
Lee H-J
,
Thinakaran G
,
Kim T-W
,
Yu G
,
Xu H
. 2003.
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
.
J Biol Chem. 278(10):7850-4.
Luo W
,
Dou F
,
Rodina A
,
Chip S
,
Kim J
,
Zhao Q
,
Moulick K
,
Aguirre J
,
Wu N
,
Greengard P
et al.
. 2007.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
.
Proc Natl Acad Sci U S A. 104(22):9511-6.
Luo P
,
Yang F
,
Li J
,
Niemeyer JE
,
Zhan F
,
Estin J
,
Zhao M
,
Li D
,
Lin W
,
Liou J-Y
et al.
. 2023.
Excitatory-inhibitory mismatch shapes node recruitment in an epileptic network.
.
Epilepsia. 64(7):1939-1950.
Luo W
,
Liu W
,
Hu X
,
Hanna M
,
Caravaca A
,
Paul SM
. 2015.
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.
.
Sci Rep. 5:11161.
M
Majewska MD
,
Harrison NL
,
Schwartz RD
,
Barker JL
,
Paul SM
. 1986.
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.
.
Science. 232(4753):1004-7.
Mannaioni G
,
Orr AG
,
Hamill CE
,
Yuan H
,
Pedone KH
,
McCoy KL
,
Palmini RBerlinguer
,
Junge CE
,
C Lee J
,
Yepes M
et al.
. 2008.
Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1.
.
J Biol Chem. 283(29):20600-11.
Martens LHerl
,
Zhang J
,
Barmada SJ
,
Zhou P
,
Kamiya S
,
Sun B
,
Min S-W
,
Gan L
,
Finkbeiner S
,
Huang EJ
et al.
. 2012.
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
.
J Clin Invest. 122(11):3955-9.
Martinez-Losa M
,
Tracy TE
,
Ma K
,
Verret L
,
Clemente-Perez A
,
Khan AS
,
Cobos I
,
Ho K
,
Gan L
,
Mucke L
et al.
. 2018.
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.
.
Neuron. 98(1):75-89.e5.
Mastroberardino PG
,
Orr AL
,
Hu X
,
Na HMee
,
J Greenamyre T
. 2008.
A FRET-based method to study protein thiol oxidation in histological preparations.
.
Free Radic Biol Med. 45(7):971-81.
Mattos C
,
Bellamacina CR
,
Peisach E
,
Pereira A
,
Vitkup D
,
Petsko GA
,
Ringe D
. 2006.
Multiple solvent crystal structures: probing binding sites, plasticity and hydration.
.
J Mol Biol. 357(5):1471-82.
McKnight NC
,
Zhong Y
,
Wold MS
,
Gong S
,
Phillips GR
,
Dou Z
,
Zhao Y
,
Heintz N
,
Zong W-X
,
Yue Z
. 2014.
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.
.
PLoS Genet. 10(10):e1004626.
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