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Burre Laboratory researchers study the mechanisms by which synaptic dysfunction triggers neurological disorders, focusing on the molecular mechanisms underlying synucleinopathies, including Parkinson’s disease, Lewy body dementia and Munc18-1-linked encephalopathies, in order to identify rescue strategies to delay or prevent pathogenic events. They apply a repertoire of disease models, which range from purified proteins and primary neurons to C. elegans and genetic mouse models, utilizing biochemical, biological and biophysical approaches.