Associate Professor of Research in Neuroscience
Email: shg3006@med.cornell.edu
Research Profile
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Shiaoching Gong is interested in understanding the molecular basis of disease. She earned her Ph.D. at SUNY Downstate Medical Center in the Department of Biochemistry and completed her postdoctoral training in the Laboratory of Molecular Immunology at The Rockefeller University. She was then recruited to head the Molecular Biology Core for the NINDS-funded Gene Expression Nervous System Atlas (GENSAT) project housed at The Rockefeller University. Working with Dr. Nathaniel Heintz, she and her team generated over 13,000 transgenic founder mice over a period of 12 years. Over 1000 of these transgenic lines were made available to the public via the Mutant Mouse Resource and Research Center. The impact that this project has made on the field of neuroscience and mouse genetics is evidenced by the 1100 published scientific studies that utilized GENSAT mice (http://www.gensat.org/gensat_papers_report.jsp).
More recently, Shiaoching has generated humanized mouse models by combining the BAC engineering strategy with CRISPR/Cas9 genome editing system. The goal of this work was to create models that would allow human disease-related genes or non-coding regions to be studied functionally in the lab. Her current research interest is to apply her expertise to generate innovative mouse and iPSC models to study molecular mechanisms of Alzheimer’s disease and frontotemporal dementia.