Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 257 results
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2011
Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C et al..  2011.  Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.. Sci Transl Med. 3(89):89ra57.
Liu W, Acín-Peréz R, Geghman KD, Manfredi G, Lu B, Li C.  2011.  Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.. Proc Natl Acad Sci U S A. 108(31):12920-4.
Birket MJ, Orr AL, Gerencser AA, Madden DT, Vitelli C, Swistowski A, Brand MD, Zeng X.  2011.  A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells.. J Cell Sci. 124(Pt 3):348-58.
Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P et al..  2011.  Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.. Nature. 469(7328):47-52.
Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH, Lindquist S et al..  2011.  A yeast model of FUS/TLS-dependent cytotoxicity.. PLoS Biol. 9(4):e1001052.
2010
Min S-W, Cho S-H, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C et al..  2010.  Acetylation of tau inhibits its degradation and contributes to tauopathy.. Neuron. 67(6):953-66.
Min S-W, Cho S-H, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C et al..  2010.  Acetylation of tau inhibits its degradation and contributes to tauopathy.. Neuron. 67(6):953-66.
Min S-W, Cho S-H, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C et al..  2010.  Acetylation of tau inhibits its degradation and contributes to tauopathy.. Neuron. 67(6):953-66.
Min S-W, Cho S-H, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C et al..  2010.  Acetylation of tau inhibits its degradation and contributes to tauopathy.. Neuron. 67(6):953-66.
Hurtado DE, Molina-Porcel L, Iba M, Aboagye AK, Paul SM, Trojanowski JQ, Lee VM-Y.  2010.  A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.. Am J Pathol. 177(4):1977-88.
Mukherjee K, Sharma M, Jahn R, Wahl MC, Südhof TC.  2010.  Evolution of CASK into a Mg2+-sensitive kinase.. Sci Signal. 3(119):ra33.
Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL.  2010.  How to improve R&D productivity: the pharmaceutical industry's grand challenge.. Nat Rev Drug Discov. 9(3):203-14.
Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL.  2010.  How to improve R&D productivity: the pharmaceutical industry's grand challenge.. Nat Rev Drug Discov. 9(3):203-14.
Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P et al..  2010.  Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.. J Pharmacol Exp Ther. 333(3):650-62.
Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P et al..  2010.  Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.. J Pharmacol Exp Ther. 333(3):650-62.
Orr AG, Sharma A, Binder NB, Miller AH, Pearce BD.  2010.  Interleukin-1 mediates long-term hippocampal dentate granule cell loss following postnatal viral infection.. J Mol Neurosci. 41(1):89-96.
Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RLA, Kim J, May J, Tocilescu MAleksandra, Liu W, Ko HSeok et al..  2010.  PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.. Proc Natl Acad Sci U S A. 107(1):378-83.
Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RLA, Kim J, May J, Tocilescu MAleksandra, Liu W, Ko HSeok et al..  2010.  PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.. Proc Natl Acad Sci U S A. 107(1):378-83.
Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RLA, Kim J, May J, Tocilescu MAleksandra, Liu W, Ko HSeok et al..  2010.  PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.. Proc Natl Acad Sci U S A. 107(1):378-83.
Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JPaul, Ringe D et al..  2010.  Polyamine pathway contributes to the pathogenesis of Parkinson disease.. Proc Natl Acad Sci U S A. 107(39):16970-5.
Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JPaul, Ringe D et al..  2010.  Polyamine pathway contributes to the pathogenesis of Parkinson disease.. Proc Natl Acad Sci U S A. 107(39):16970-5.
Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JPaul, Ringe D et al..  2010.  Polyamine pathway contributes to the pathogenesis of Parkinson disease.. Proc Natl Acad Sci U S A. 107(39):16970-5.
Mullasseril P, Hansen KB, Vance KM, Ogden KK, Yuan H, Kurtkaya NL, Santangelo R, Orr AG, Le P, Vellano KM et al..  2010.  A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.. Nat Commun. 1:90.
2009
Bateman RJ, Siemers ER, Mawuenyega KG, Wen G, Browning KR, Sigurdson WC, Yarasheski KE, Friedrich SW, DeMattos RB, May PC et al..  2009.  A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.. Ann Neurol. 66(1):48-54.
Bateman RJ, Siemers ER, Mawuenyega KG, Wen G, Browning KR, Sigurdson WC, Yarasheski KE, Friedrich SW, DeMattos RB, May PC et al..  2009.  A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.. Ann Neurol. 66(1):48-54.