Publications

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2026

Liu Y, Feng W, Aikedan A, Lee S-I, Bhagwat M, Nagiri RKumar, Wong MYing, Amin S, Qu W, Zhu J et al.. 2026. cGAS inhibition delays TDP-43-driven ALS Pathogenesis.. bioRxiv.

Huang Y, Fan L, Wong MYing, Lei Z, Krishnamachary B, Zhu D, Cadiz M, Nagiri RKumar, Ye P, Norman K et al.. 2026. cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy.. bioRxiv.

Li X, Chen Y, Wang H, Zhang X, Guiberson NGuy Lewis, Li X, Burré J, Peng J, Zhang H, Yue Z. 2026. Disruption of the LRRK2 substrate RAB12 facilitates neurotransmission and causes hyperactivity in mice.. NPJ Parkinsons Dis. 12(1)

Castagnola C, Marongiu R, Wan Y, Torres ERuth S, Fan L, Jang MWendy, Cui Q, Kim J, Ye P, Zhu J et al.. 2026. Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity.. bioRxiv.

2025

Naguib S, Lopez-Lee C, Torres ERuth, Lee S-I, Zhu J, Zhu D, Ye P, Norman K, Zhao M, Wong MYing et al.. 2025. APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition.. bioRxiv.

Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung Y-F, Yang Q et al.. 2025. Brain-wide neuronal circuit connectome of human glioblastoma.. Nature. 641(8061):222-231.

Ju H, Kim I-D, Pavlova I, Mu S, Park KWoo, Minkler J, Madkoor A, Wang W, Wang X, Wu Z et al.. 2025. Ischemic Conditioning Promotes Transneuronal Survival and Stroke Recovery via CD36-Mediated Efferocytosis.. Circ Res. 136(5):e34-e51.

Clelland CDudley, Fan L, Saloner R, Etchegaray JIker, Altobelli CRichard, Salomonsson S, Maltos AM, Sachdev A, Zhu J, Lee S-I et al.. 2025. Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.. Commun Biol. 8(1):971.

Naguib S, Lopez-Lee C, Torres ERuth, Lee S-I, Zhu J, Zhu D, Ye P, Norman K, Zhao M, Wong MYing et al.. 2025. The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway.. Immunity. 58(8):1931-1947.e9.

Chen H, Fan L, Wong MYing, Ambaw YA, Zhu J, Norman K, Ye P, Foxe N, Zhu D, Wan Y et al.. 2025. STING-IFN-CH25H lipid axis links innate immune activation to tau pathology.. bioRxiv.

2024

Rodriguez-Rodriguez P, Arroyo-Garcia LEnrique, Tsagkogianni C, Li L, Wang W, Végvári Á, Salas-Allende I, Plautz Z, Cedazo-Minguez A, Sinha SC et al.. 2024. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons.. Brain. 147(7):2384-2399.

Bravo CParra, Giani AMaria, Madero-Pérez J, Zhao Z, Wan Y, Samelson AJ, Wong MYing, Evangelisti A, Cordes E, Fan L et al.. 2024. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. Cell. 187(10):2446-2464.e22.

Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R et al.. 2024. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.. Mol Cell Neurosci. 130:103954.

Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y et al.. 2024. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. J Clin Invest. 134(3)

Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al.. 2024. Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.. Nat Commun. 15(1):10269.

Lopez-Lee C, Kodama L, Fan L, Zhu D, Zhu J, Wong MYing, Ye P, Norman K, Foxe NR, Ijaz L et al.. 2024. Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination.. Science. 386(6725):eadk7844.

2023