Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 158 results

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2025

Naguib S, Lopez-Lee C, Torres ERuth, Lee S-I, Zhu J, Zhu D, Ye P, Norman K, Zhao M, Wong MYing et al.. 2025. APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition.. bioRxiv.

Naguib S, Lopez-Lee C, Torres ERuth, Lee S-I, Zhu J, Zhu D, Ye P, Norman K, Zhao M, Wong MYing et al.. 2025. APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition.. bioRxiv.

Naguib S, Lopez-Lee C, Torres ERuth, Lee S-I, Zhu J, Zhu D, Ye P, Norman K, Zhao M, Wong MYing et al.. 2025. APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition.. bioRxiv.

Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung Y-F, Yang Q et al.. 2025. Brain-wide neuronal circuit connectome of human glioblastoma.. Nature. 641(8061):222-231.

Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung Y-F, Yang Q et al.. 2025. Brain-wide neuronal circuit connectome of human glioblastoma.. Nature. 641(8061):222-231.

Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung Y-F, Yang Q et al.. 2025. Brain-wide neuronal circuit connectome of human glioblastoma.. Nature. 641(8061):222-231.

Zhou C, Hardin EJ, Zimmer TS, Jackvony S, Barnett D, Khobrekar N, Giacomelli E, Studer L, Orr AL, Orr AG. 2025. Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology.. Neurobiol Dis. 211:106939.

Zhou C, Hardin EJ, Zimmer TS, Jackvony S, Barnett D, Khobrekar N, Giacomelli E, Studer L, Orr AL, Orr AG. 2025. Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology.. Neurobiol Dis. 211:106939.

Gao V, Chlebowicz J, Gaskin K, Briano JA, Komer LE, Pineda A, Jhalani S, Ahmad S, Uwaifo E, Black LS et al.. 2025. Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy.. Nat Commun. 16(1):4079.

2024

Carling GK, Fan L, Foxe NR, Norman K, Ye P, Wong MYing, Zhu D, Yu F, Xu J, Yarahmady A et al.. 2024. Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. bioRxiv.

Carling GK, Fan L, Foxe NR, Norman K, Ye P, Wong MYing, Zhu D, Yu F, Xu J, Yarahmady A et al.. 2024. Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. bioRxiv.

Carling GK, Fan L, Foxe NR, Norman K, Wong MYing, Zhu D, Corona C, Razzoli A, Yu F, Yarahmady A et al.. 2024. Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. Neuron.

Carling GK, Fan L, Foxe NR, Norman K, Wong MYing, Zhu D, Corona C, Razzoli A, Yu F, Yarahmady A et al.. 2024. Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. Neuron.

Cheng F, Wang F, Tang J, Zhou Y, Fu Z, Zhang P, Haines JL, Leverenz JB, Gan L, Hu J et al.. 2024. Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease.. Cell Rep Med. 5(2):101379.

Cheng F, Wang F, Tang J, Zhou Y, Fu Z, Zhang P, Haines JL, Leverenz JB, Gan L, Hu J et al.. 2024. Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease.. Cell Rep Med. 5(2):101379.

Zimmer TS, Orr AL, Orr AG. 2024. Astrocytes in selective vulnerability to neurodegenerative disease.. Trends Neurosci. 47(4):289-302.

Iannone AF, Akgül G, Zhang R, Wacks S, Hussein N, Macias CGinelly, Donatelle A, Bauriedel JMJ, Wright C, Abramov D et al.. 2024. The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex.. Cell Rep. 43(8):114531.

Buchholz S, Bell-Simons M, Cakmak C, Klimek J, Gan L, Zempel H. 2024. Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau.. Methods Mol Biol. 2754:533-549.

Meadows SM, Palaguachi F, Jang MWendy, Licht-Murava A, Barnett D, Zimmer TS, Zhou C, McDonough SR, Orr AL, Orr AG. 2024. Hippocampal astrocytes induce sex-dimorphic effects on memory.. Cell Rep. 43(6):114278.

Meadows SM, Palaguachi F, Jang MWendy, Licht-Murava A, Barnett D, Zimmer TS, Zhou C, McDonough SR, Orr AL, Orr AG. 2024. Hippocampal astrocytes induce sex-dimorphic effects on memory.. Cell Rep. 43(6):114278.

Bravo CParra, Giani AMaria, Madero-Pérez J, Zhao Z, Wan Y, Samelson AJ, Wong MYing, Evangelisti A, Cordes E, Fan L et al.. 2024. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. Cell. 187(10):2446-2464.e22.

Bravo CParra, Giani AMaria, Madero-Pérez J, Zhao Z, Wan Y, Samelson AJ, Wong MYing, Evangelisti A, Cordes E, Fan L et al.. 2024. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. Cell. 187(10):2446-2464.e22.

Bravo CParra, Giani AMaria, Madero-Pérez J, Zhao Z, Wan Y, Samelson AJ, Wong MYing, Evangelisti A, Cordes E, Fan L et al.. 2024. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. Cell. 187(10):2446-2464.e22.

Zheng X, Wu B, Liu Y, Simmons SK, Kim K, Clarke GS, Ashiq A, Park J, Li J, Wang Z et al.. 2024. Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development.. Cell. 187(13):3236-3248.e21.

Zheng X, Wu B, Liu Y, Simmons SK, Kim K, Clarke GS, Ashiq A, Park J, Li J, Wang Z et al.. 2024. Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development.. Cell. 187(13):3236-3248.e21.