Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 442 results
Author Title Type [ Year(Desc)]
2025
Lee J, Kang R, Park S, Saliu IO, Son M, Voorhees JR, Dimitry JM, Quillin EI, Woodie LN, Lananna BV et al..  2025.  REV-ERBα regulates brain NAD+ levels and tauopathy via an NFIL3-CD38 axis.. Nat Aging. 5(10):2070-2085.
Mossa A, Dierdorff L, Lukin J, Garcia-Forn M, Wang W, Mamashli F, Park Y, Fiorenzani C, Akpinar Z, Kamps J et al..  2025.  Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X.. Nat Commun. 16(1):4512.
Belchikov N, Hu W, Fan L, Joglekar A, He Y, Foord C, Jarroux J, Hsu J, Pollard S, Amin S et al..  2025.  A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain.. Cell Rep. 44(9):116198.
Naseri NN, Xu T, Chantarawong S, Patrie SM, Kelleher NL, Sharma M, Shalem O, Rhoades E.  2025.  Specific Combinations of Physiological Tau Phosphorylation Regulate Tau-Microtubule Interactions in Developing Neurons.. bioRxiv.
Chen H, Fan L, Wong MYing, Ambaw YA, Zhu J, Norman K, Ye P, Foxe N, Zhu D, Wan Y et al..  2025.  STING-IFN-CH25H lipid axis links innate immune activation to tau pathology.. bioRxiv.
Gao V, Chlebowicz J, Gaskin K, Briano JA, Komer LE, Pineda A, Jhalani S, Ahmad S, Uwaifo E, Black LS et al..  2025.  Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy.. Nat Commun. 16(1):4079.
Li D, Liu K, Li D, Brunger A, Li C, Burré J, Diao J.  2025.  α-Synuclein condensation in synaptic vesicle function and synucleinopathies.. Trends Cell Biol.
2026
Liu Y, Feng W, Aikedan A, Lee S-I, Bhagwat M, Nagiri RKumar, Wong MYing, Amin S, Qu W, Zhu J et al..  2026.  cGAS inhibition delays TDP-43-driven ALS Pathogenesis.. bioRxiv.
Huang Y, Fan L, Wong MYing, Lei Z, Krishnamachary B, Zhu D, Cadiz M, Nagiri RKumar, Ye P, Norman K et al..  2026.  cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy.. bioRxiv.
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CParra, Bose RS, Travaglini KJ, Lam VL, Goodness D, Ta T et al..  2026.  CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.. Cell. 189(5):1517-1534.e19.
Li X, Chen Y, Wang H, Zhang X, Guiberson NGuy Lewis, Li X, Burré J, Peng J, Zhang H, Yue Z.  2026.  Disruption of the LRRK2 substrate RAB12 facilitates neurotransmission and causes hyperactivity in mice.. NPJ Parkinsons Dis. 12(1)
Feng W, Aikedan A, Sinha SC, Gan L.  2026.  Expanding roles of cGAS-STING signaling in neuroinflammation.. J Clin Invest. 136(11)
Castagnola C, Marongiu R, Wan Y, Torres ERuth S, Fan L, Jang MWendy, Cui Q, Kim J, Ye P, Zhu J et al..  2026.  Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity.. bioRxiv.
Chlebowicz J, Ivanova V, Burré J.  2026.  New insights into synaptic vesicle dysfunction in Parkinson's disease.. J Parkinsons Dis. :1877718X261431203.
Zolin A, Weber SA, Xie YXin, Burré J.  2026.  Propagation of α-synuclein pathology: models, mechanisms and future goals.. Mol Neurodegener Adv. 2(1):26.
Pan J-P, Wang P-J, Zhang J, Knapskog A-B, Watne LOtto, Wang H-L, Lagartos-Donate MJose, Lautrup S, Mao L-P, Wang Q et al..  2026.  Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology.. Nat Aging. 6(5):1079-1102.
Davtyan H, Naguib S, Voskobiynyk Y, Chadarevian JPaul, Capocchi JK, Giacchino JL, Eskandari-Sedighi G, DeNittis V, Ford JB, Agababian A et al..  2026.  Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.. Res Sq.