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An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from gene mutations.. Alzheimers Dement (N Y). 3(4):507-512.
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Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.. Mol Neurodegener. 11(1):47.
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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.. Nature. 549(7673):523-527.
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Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation.. Acta Neuropathol. 125(4):581-93.
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Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.. J Exp Med. 211(10):1937-45.
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Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.. Proc Natl Acad Sci U S A. 114(19):5029-5034.
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Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.. Acta Neuropathol Commun. 7(1):159.
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Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.. Mol Neurodegener. 15(1):2.