Publications

Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR.  2004.  The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.. Proc Natl Acad Sci U S A. 101(24):9103-8.

Mattos C, Bellamacina CR, Peisach E, Pereira A, Vitkup D, Petsko GA, Ringe D.  2006.  Multiple solvent crystal structures: probing binding sites, plasticity and hydration.. J Mol Biol. 357(5):1471-82.

Das C, Hoang QQ, Kreinbring CA, Luchansky SJ, Meray RK, Ray SS, Lansbury PT, Ringe D, Petsko GA.  2006.  Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.. Proc Natl Acad Sci U S A. 103(12):4675-80.

Lieberman RL, Wustman BA, Huertas P, Powe AC, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA.  2007.  Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.. Nat Chem Biol. 3(2):101-7.

Landon MR, Lieberman RL, Hoang QQ, Ju S, Caaveiro JMM, Orwig SD, Kozakov D, Brenke R, Chuang G-Y, Beglov D et al..  2009.  Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.. J Comput Aided Mol Des. 23(8):491-500.

Lieberman RL, J D'Aquino A, Ringe D, Petsko GA.  2009.  Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.. Biochemistry. 48(22):4816-27.

Ringe D, Petsko GA.  2009.  What are pharmacological chaperones and why are they interesting? J Biol. 8(9):80.

Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JPaul, Ringe D et al..  2010.  Polyamine pathway contributes to the pathogenesis of Parkinson disease.. Proc Natl Acad Sci U S A. 107(39):16970-5.

Auclair JR, Boggio KJ, Petsko GA, Ringe D, Agar JN.  2010.  Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis.. Proc Natl Acad Sci U S A. 107(50):21394-9.

Bosco DA, LaVoie MJ, Petsko GA, Ringe D.  2011.  Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.. Cold Spring Harb Perspect Biol. 3(10):a007500.

Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH, Lindquist S et al..  2011.  A yeast model of FUS/TLS-dependent cytotoxicity.. PLoS Biol. 9(4):e1001052.

Davies CW, Chaney J, Korbel G, Ringe D, Petsko GA, Ploegh H, Das C.  2012.  The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).. Bioorg Med Chem Lett. 22(12):3900-4.

Bharadwaj PR, Verdile G, Barr RK, Gupta V, Steele JW, M Lachenmayer L, Yue Z, Ehrlich ME, Petsko G, Ju S et al..  2012.  Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.. J Alzheimers Dis. 32(4):949-67.

Auclair JR, Somasundaran M, Green KM, Evans JE, Schiffer CA, Ringe D, Petsko GA, Agar JN.  2012.  Mass spectrometry tools for analysis of intermolecular interactions.. Methods Mol Biol. 896:387-98.

Edayathumangalam R, Wu R, Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC et al..  2013.  Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.. Proc Natl Acad Sci U S A. 110(44):17820-5.

Liu CFeng, Liu D, Momb J, Thomas PW, Lajoie A, Petsko GA, Fast W, Ringe D.  2013.  A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.. Biochemistry. 52(9):1603-10.

Auclair JR, Johnson JL, Liu Q, Salisbury JP, Rotunno MS, Petsko GA, Ringe D, Brown RH, Bosco DA, Agar JN.  2013.  Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage.. Biochemistry. 52(36):6137-44.

Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JMM, Pybus B, Ringe D, Petsko GA, Boxer SG et al..  2013.  Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.. Proc Natl Acad Sci U S A. 110(28):E2552-61.

Auclair JR, Brodkin HR, J D'Aquino A, Petsko GA, Ringe D, Agar JN.  2013.  Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase.. Biochemistry. 52(36):6145-50.

Auclair JR, Salisbury JP, Johnson JL, Petsko GA, Ringe D, Bosco DA, Agar NYR, Santagata S, Durham HD, Agar JN.  2014.  Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.. Proteomics. 14(10):1152-7.

Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA.  2014.  Pharmacological chaperones stabilize retromer to limit APP processing.. Nat Chem Biol. 10(6):443-9.

Kreinbring CA, Remillard SP, Hubbard P, Brodkin HR, Leeper FJ, Hawksley D, Lai EY, Fulton C, Petsko GA, Ringe D.  2014.  Structure of a eukaryotic thiaminase I.. Proc Natl Acad Sci U S A. 111(1):137-42.