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Found 24 results
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Sharma, Manu
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Burré J
,
Sharma M
,
Südhof TC
. 2014.
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
.
Proc Natl Acad Sci U S A. 111(40):E4274-83.
T
Abramov D
,
Guiberson NGuy Lewis
,
Daab A
,
Na Y
,
Petsko GA
,
Sharma M
,
Burré J
. 2020.
Targeted stabilization of Munc18-1 function via pharmacological chaperones.
.
EMBO Mol Med. :e12354.
S
Burré J
,
Sharma M
,
Südhof TC
. 2012.
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities.
.
J Neurosci. 32(43):15227-42.
Carnazza KE
,
Komer LE
,
Xie YXue
,
Pineda A
,
Briano JAntonio
,
Gao V
,
Na Y
,
Ramlall T
,
Buchman VL
,
Eliezer D
et al.
. 2022.
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins.
.
Cell Rep. 39(2):110675.
Lee SHun
,
Sharma M
,
Südhof TC
,
Shen J
. 2014.
Synaptic function of nicastrin in hippocampal neurons.
.
Proc Natl Acad Sci U S A. 111(24):8973-8.
R
Benharouga M
,
Sharma M
,
So J
,
Haardt M
,
Drzymala L
,
Popov M
,
Schwapach B
,
Grinstein S
,
Du K
,
Lukacs GL
. 2003.
The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia.
.
J Biol Chem. 278(24):22079-89.
P
Sharma M
,
Burré J
,
Südhof TC
. 2012.
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
.
Sci Transl Med. 4(147):147ra113.
Burré J
,
Vivona S
,
Diao J
,
Sharma M
,
Brunger AT
,
Südhof TC
. 2013.
Properties of native brain α-synuclein.
.
Nature. 498(7453):E4-6;discussionE6-7.
N
Diao J
,
Burré J
,
Vivona S
,
Cipriano DJ
,
Sharma M
,
Kyoung M
,
Südhof TC
,
Brunger AT
. 2013.
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.
.
Elife. 2:e00592.
M
Sharma M
,
Pampinella F
,
Nemes C
,
Benharouga M
,
So J
,
Du K
,
Bache KG
,
Papsin B
,
Zerangue N
,
Stenmark H
et al.
. 2004.
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.
.
J Cell Biol. 164(6):923-33.
Acuna C
,
Guo Q
,
Burré J
,
Sharma M
,
Sun J
,
Südhof TC
. 2014.
Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity.
.
Neuron. 82(5):1088-100.
E
Mukherjee K
,
Sharma M
,
Jahn R
,
Wahl MC
,
Südhof TC
. 2010.
Evolution of CASK into a Mg2+-sensitive kinase.
.
Sci Signal. 3(119):ra33.
D
Du K
,
Sharma M
,
Lukacs GL
. 2005.
The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.
.
Nat Struct Mol Biol. 12(1):17-25.
Burré J
,
Sharma M
,
Südhof TC
. 2015.
Definition of a molecular pathway mediating α-synuclein neurotoxicity.
.
J Neurosci. 35(13):5221-32.
C
Sharma M
,
Burré J
,
Südhof TC
. 2011.
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
.
Nat Cell Biol. 13(1):30-9.
Sharma M
,
Burré J
,
Bronk P
,
Zhang Y
,
Xu W
,
Südhof TC
. 2012.
CSPα knockout causes neurodegeneration by impairing SNAP-25 function.
.
EMBO J. 31(4):829-41.
Naseri NN
,
Wang H
,
Guo J
,
Sharma M
,
Luo W
. 2019.
The complexity of tau in Alzheimer's disease.
.
Neurosci Lett. 705:183-194.
Benharouga M
,
Sharma M
,
Lukacs GL
. 2002.
CFTR folding and maturation in cells.
.
Methods Mol Med. 70:229-43.
Burré J
,
Sharma M
,
Südhof TC
. 2018.
Cell Biology and Pathophysiology of α-Synuclein.
.
Cold Spring Harb Perspect Med. 8(3)
Mukherjee K
,
Sharma M
,
Urlaub H
,
Bourenkov GP
,
Jahn R
,
Südhof TC
,
Wahl MC
. 2008.
CASK Functions as a Mg2+-independent neurexin kinase.
.
Cell. 133(2):328-39.
A
Naseri N
,
Sharma M
,
Velinov M
. 2020.
Autosomal dominant neuronal ceroid lipofuscinosis: Clinical features and molecular basis.
.
Clin Genet.
Etherton MR
,
Tabuchi K
,
Sharma M
,
Ko J
,
Südhof TC
. 2011.
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
.
EMBO J. 30(14):2908-19.
Burré J
,
Sharma M
,
Tsetsenis T
,
Buchman V
,
Etherton MR
,
Südhof TC
. 2010.
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
.
Science. 329(5999):1663-7.
Naseri NN
,
Ergel B
,
Kharel P
,
Na Y
,
Huang Q
,
Huang R
,
Dolzhanskaya N
,
Burré J
,
Velinov MT
,
Sharma M
. 2020.
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
.
Nat Struct Mol Biol. 27(2):192-201.