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eft to right: Stephanie Jackvony (Anna Orr Lab), Lauren Komer (Jacqueline Burré Lab) and Gillian Carling (Li Gan Lab)

Congratulations! Graduate Students at Appel Institute are Awarded F31 Fellowships!

Graduate students within the Appel Institute, Stephanie Jackvony, Lauren Komer, and Gillian Carling have been awarded F31 predoctoral fellowships from the NIH. Stephanie Jackvony’s project is titled “Effects of TDP-43 pathology on innate antiviral mechanisms in neurodegenerative disease.” Lauren Komer will continue studying “The role of beta-synuclein in synaptic vesicle release.” Gillian Carling’s research is titled “Trem2-APOE Pathway in Alzheimer's Disease: Exploring the differential...


Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models

Congratulations to the Sharma lab for their recent work on alpha-synuclein pathogenesis recently published in Nature Communications!

In collaboration with the Burré lab, also at the Appel Institute, the team led by Dr. Manu Sharma found that pathogenic alpha-synuclein species accumulate within neuronal lysosomes and are released through SNARE-dependent lysosomal exocytosis, providing a novel mechanism by which pathogenic alpha-synuclein transmit from neuron-to-neuron and spread...


A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

A collaborative effort between the Gan lab at the Appel Institute and the Kampmann lab at UCSF reveals regulators of disease states in a recent publication out now in Nature Neuroscience. The authors devised a fast and efficient method to generate induced microglia from iPSCs and developed CRISPRi/a platforms that can systematically discover regulators of microglia states and allow researchers to determine their function and therapeutic value. See the press release from WCM Newsroom...

Weill Cornell Medicine Helen & Robert Appel Alzheimer’s Disease Research Institute 413 E. 69th St. New York, NY 10021