Congratulations! Debra Abramov from Burré lab has received a NRSA F30 fellowship from the NICHD

Debra Abramov from the Burré Lab has received a NRSA F30 fellowship from the NICHD, to investigate how Munc18-1 mutations disrupt syntaxin-5 stability and general secretory trafficking.

Despite a known genetic cause, no effective treatments exist for Munc18-1 related disorders, which cause intractable epilepsy, severe intellectual disability, and other severe neurologic symptoms in children. The aim of my proposal is to investigate the non-synaptic neuronal deficits that are caused by these genetic mutations. An understanding of these deficits will be essential to testing future corrective strategies for these devastating diseases and others caused by similar mechanisms.

Weill Cornell Medicine Helen & Robert Appel Alzheimer’s Disease Research Institute 413 E. 69th St. New York, NY 10021