Congratulations! New R01 from NIH Awarded to Dr. Anna Orr

Dr. Orr and her team will investigate the effects of astrocytic TDP-43 dysregulation on hippocampal function

TDP-43 is a nucleic acid-binding protein linked to neurodegenerative disorders, but its roles in non-neuronal cells like astrocytes are poorly understood. The proposed research will examine how astrocytic TDP-43 affects glial-neuronal interactions and cognitive impairments. These studies will unravel novel intracellular and intercellular molecular mechanisms underlying cognitive deficits in neurodegenerative disease and may reveal promising therapeutic strategies for TDP-43-related pathology in dementia.

Weill Cornell Medicine Helen & Robert Appel Alzheimer’s Disease Research Institute 413 E. 69th St. New York, NY 10021