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Congratulations! New R01 from NIH awarded to Dr. Wenjie Luo

Dr. Luo will lead the investigation on the essential roles of Dap12 in tau metabolism and inflammation in Alzheimer’s disease

DAP12 (also called TYROBP) acts as an adaptor protein in microglia involved in the cross-interaction of signaling networks of microglial surface immune receptors, including AD risk gene TREM2. DAP12 has been implicated as a central player in an AD-associated microglia specific module. Dr. Luo will investigate the functions of DAP12 in regulating microglia-mediated tau metabolism and inflammation and dissect the molecular and cellular mechanism underpinning these activities.

Weill Cornell Medicine Helen & Robert Appel Alzheimer’s Disease Research Institute 413 E. 69th St. New York, NY 10021