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DAP12 (also called TYROBP) acts as an adaptor protein in microglia involved in the cross-interaction of signaling networks of microglial surface immune receptors, including AD risk gene TREM2. DAP12 has been implicated as a central player in an AD-associated microglia specific module. Dr. Luo will investigate the functions of DAP12 in regulating microglia-mediated tau metabolism and inflammation and dissect the molecular and cellular mechanism underpinning these activities.
