A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

A collaborative effort between the Gan lab at the Appel Institute and the Kampmann lab at UCSF reveals regulators of disease states in a recent publication out now in Nature Neuroscience. The authors devised a fast and efficient method to generate induced microglia from iPSCs and developed CRISPRi/a platforms that can systematically discover regulators of microglia states and allow researchers to determine their function and therapeutic value. See the press release from WCM Newsroom here. Click here for open access to the full article.

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