Distinguished Chemist, Dr. Subhash Sinha, Joining Appel Institute to Boost Translational Research

Dr. Sinha is a synthetic medicinal chemist at the Helen and Robert Appel Alzheimer’s Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine. Dr. Sinha received his doctorate in Chemistry-Medicinal Chemistry in 1987 from Banaras Hindu University, India. He completed postdoctoral training at Tohoku University, Japan, Technion-Israel Institute of Technology, Israel, and at The Scripps Research Institute, California. He joined the Scripps faculty as an Assistant Professor in 1994 and as Associate Professor (of Medicinal Chemistry) in 1999, before moving to the Laboratory of Molecular and Cellular Neurosciences at Rockefeller University in July 2013 and to the Weill Cornell Medicine in March 2020.

Dr. Sinha has worked in the diverse area of synthetic and medicinal chemistry, including reaction method development and natural product synthesis, enzyme and antibody catalysis, chemical antibody re-programming and drug conjugates, and medicinal and prodrug chemistry. At the RU in collaboration with the Greengard laboratory, Dr. Sinha has identified and developed hit-to-lead compounds for reducing production and oligomerization of Abeta peptides and Abeta levels through mediating autophagy, established the DNA-encoded chemical library synthesis, and provided various chemistry-core support to the lab members. At Appel Institute, Dr. Sinha will collaborate closely with other investigators to discover novel small molecule compounds targeting disease modifying pathways for treatment of neurodegenerative diseases.

Weill Cornell Medicine Helen & Robert Appel Alzheimer’s Disease Research Institute 413 E. 69th St. New York, NY 10021