The Gan lab has published a new study in Neuron, where Carling et al. investigate the mechanistic underpinnings of the strongest Alzheimer's Disease risk factors: APOE4 and TREM2-R47H. Carling et al. find that the combination of APOE4 and TREM2-R47H risk factors in mice harboring the P301S tau mutation amplifies microglial cGAS-STING signaling and related senescence, specifically in female mice. This work highlights cGAS-STING and senescence pathways as potential drivers of AD risk in females.
Read the full paper HERE
