News and Events | Page 7 | Helen & Robert Appel Alzheimer’s Disease Research Institute

Synaptic vesicle binding highlights interactions between synucleins are important to brain health

A collaboration between the Burré and Sharma labs, “Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins,” has recently been published in Cell Reports. Their work furthers our understanding of the composition of synuclein heteromultimers on the synaptic vesicle surface and shows that these synuclein heteromultimers govern the amount of physiologically active α-synuclein on synaptic vesicles. These findings highlight the need for a balance of synucleins for...

Congratulations! The Appel and BMRI Summer Diversity Scholars Present Their Research

As part of the Appel and BMRI Summer Diversity Scholars Program, the two scholars, Daiyan Ahmed and Elena Ajayi will present their findings during a virtual presentation on Friday, August 12th at 10:30am. Daiyan Ahmed worked with Dr. Wenjie Luo and postdoctoral associate Dr. Hao Chen on his project titled “DAP-12 regulates tau dependent neuroinflammation in Alzheimer's Disease mice with tauopathy.” Elena Ajayi was mentored by Dr. Jonathan Victor on her project titled “Is the visual system...

Mapping Dementia-Linked Protein Interactions Yields Potential New Treatment Targets

We’re excited to share our latest research out in CellPress NOW! Using APEX and AP-MS proteomics, we mapped Tau interactomes that were modified by neuronal activity and FTD mutations in hiPSC-derived neurons. Read the press release here. The full article is open access and can be read...

Targeting the Brain’s Immune Cells May Help Prevent or Treat Alzheimer’s Disease

Our recent study in Science Translational Medicine identifies a TREM2 R47H-specific microglial subpopulation in human AD brain and tauopathy mice, reminiscent of DAM and AKT hyperactivation which can be rescued by pharmacological AKT inhibition. Read the full article here.

The Ninth Annual Appel Alzheimer's Disease Research Institute Symposium is scheduled virtually on Tuesday, November 9th, 2021

The Ninth Annual Appel Alzheimer's Disease Research Institute Symposium is scheduled virtually on Tuesday, November 9th, 2021 from 2:30PM - 4:00PM.

This is an outstanding annual event hosted by Dean Choi, Appel Alzheimer's Institute and the Feil Family BMRI. Dr. Li Gan, Director of the Appel Institute will open the symposium, followed by four cutting edge scientific presentations by Dr. Jacqueline Burré from Weill Cornell Medicine, Dr. Ana Maria Cuervo from Albert Einstein College of...