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AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.

TitleAD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Publication TypeJournal Article
Year of Publication2021
AuthorsSayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MYing, Horowitz R, Ye P, Mathys H, Wang M, Niu X, Mazutis L, Jiang X, Wang X, Gao F, Brendel M, Telpoukhovskaia M, Tracy TE, Frost G, Zhou Y, Li Y, Qiu Y, Cheng Z, Yu G, Hardy J, Coppola G, Wang F, DeTure MA, Zhang B, Xie L, Trajnowski JQ, M Y Lee V, Gong S, Sinha SC, Dickson DW, Luo W, Gan L
JournalSci Transl Med
Volume13
Issue622
Paginationeabe3947
Date Published2021 Dec
ISSN1946-6242
Abstract

[Figure: see text].

DOI10.1126/scitranslmed.abe3947
Alternate JournalSci Transl Med
PubMed ID34851693