The AD odyssey 2023: Tales of single cell.

TitleThe AD odyssey 2023: Tales of single cell.
Publication TypeJournal Article
Year of Publication2023
AuthorsLuo W, Qu W, Gan L
JournalCell
Volume186
Issue20
Pagination4257-4259
Date Published2023 Sep 28
ISSN1097-4172
KeywordsAlzheimer Disease, Humans, RNA, Small Nuclear, Sequence Analysis, RNA
Abstract

Deciphering cellular changes in Alzheimer's disease (AD) using large cohorts with defined clinical stages is essential for understanding the diverse trajectories of AD progression. In this issue of Cell, five studies harnessed the power of single-nuclei RNA sequencing (snRNA-seq) and single-nuclei ATAC sequencing (snATAC-seq) at unprecedented scale and revealed exciting insights into cell-type-specific mechanisms underlying the progression of AD pathogenesis.

DOI10.1016/j.cell.2023.09.001
Alternate JournalCell
PubMed ID37774675