Title | Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference. |
Publication Type | Journal Article |
Year of Publication | 2025 |
Authors | Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S, Da Mesquita S, Dabin LC, Devanand D, Duran-Laforet V, Elyaman W, Evans EE, Fitzgerald-Bocarsly P, Foley KE, Harms AS, Heneka MT, Hong S, Huang Y-WA, Jackvony S, Lai L, Le Guen Y, Lemere CA, Liddelow SA, Martin-Peña A, Orr AG, Quintana FJ, Ramey GD, Rexach JE, Rizzo SJS, Sexton C, Tang AS, Torrellas JG, Tsai AP, van Olst L, Walker KA, Wharton W, Tansey MGámez, Wilcock DM |
Journal | Alzheimers Dement |
Volume | 21 |
Issue | 1 |
Pagination | e14291 |
Date Published | 2025 Jan |
ISSN | 1552-5279 |
Keywords | Alzheimer Disease, Animals, Brain, Congresses as Topic, Dementia, Humans |
Abstract | The immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell-mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown to significantly contribute to Alzheimer's disease (AD) pathology, the nature and extent of immune responses in the brain in the context of AD and related dementias (ADRD) remain unclear. Furthermore, the roles of the peripheral immune system in driving ADRD pathology remain incompletely elucidated. In March of 2023, the Alzheimer's Association convened the Alzheimer's Association International Conference (AAIC), Advancements: Immunity, to discuss the roles of the immune system in ADRD. A wide range of topics were discussed, such as animal models that replicate human pathology, immune-related biomarkers and clinical trials, and lessons from other fields describing immune responses in neurodegeneration. This manuscript presents highlights from the conference and outlines avenues for future research on the roles of immunity in neurodegenerative disorders. HIGHLIGHTS: The immune system plays a central role in the pathogenesis of Alzheimer's disease. The immune system exerts numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The 2023 AAIC, Advancements: Immunity, encouraged discussions and collaborations on understanding the role of the immune system. |
DOI | 10.1002/alz.14291 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 39692624 |
PubMed Central ID | PMC11772715 |
Grant List | T32 GM007618 / GM / NIGMS NIH HHS / United States U19AG07486 / AG / NIA NIH HHS / United States U54AG054345 / AG / NIA NIH HHS / United States F30 AG079504 / AG / NIA NIH HHS / United States / / Alzheimer's Association Zenith / U54AG065187 / AG / NIA NIH HHS / United States F31 AG079616 / AG / NIA NIH HHS / United States 3R01AG067581-04S1 / AG / NIA NIH HHS / United States R01 AG066203 / AG / NIA NIH HHS / United States / / John Douglas French Alzheimer's Foundation / RF1 AG080556 / AG / NIA NIH HHS / United States U54 AG065187 / AG / NIA NIH HHS / United States T32GM007618 / / Medical Scientist Training Program / R01 AG053961 / AG / NIA NIH HHS / United States R01 AG10882 / NH / NIH HHS / United States PF-IMP-870699 / / Parkinson's Foundation / K08 NS105916 / NH / NIH HHS / United States RF1NS128800 / NH / NIH HHS / United States 1F31AG079616-01 / AG / NIA NIH HHS / United States R21AG067368-02S1 / NH / NIH HHS / United States U54 AG054345 / AG / NIA NIH HHS / United States 1RF1AG080556-01A1 / / NIH/NIA / A2022006F / / BrightFocus Foundation / R01 AG083943 / AG / NIA NIH HHS / United States R01 AG075802 / AG / NIA NIH HHS / United States WE.06-2023-03 / / Alzheimer Nederland Impulssubsidie / / / Infectious Diseases Society of America / R01AG060393 / AG / NIA NIH HHS / United States R01AG067581 / NH / NIH HHS / United States R21 AG072234 / AG / NIA NIH HHS / United States U54 AG065181 / AG / NIA NIH HHS / United States R01 AG060393 / AG / NIA NIH HHS / United States R21AG072234 / AG / NIA NIH HHS / United States R21AG073882 / NH / NIH HHS / United States NIH P30 AR070155 / AR / NIAMS NIH HHS / United States 5R01AG053961 / NH / NIH HHS / United States R01 AG075802 / NH / NIH HHS / United States 1R01NS118569 / / NINDS/NIA / RF1 NS128626 / NS / NINDS NIH HHS / United States 5R01AG067581 / AG / NIA NIH HHS / United States 1F30AG079504-01 / AG / NIA NIH HHS / United States R24 AG066599 / AG / NIA NIH HHS / United States P30 AR070155 / AR / NIAMS NIH HHS / United States RF1 AG041845 / AG / NIA NIH HHS / United States R21 AG073882 / AG / NIA NIH HHS / United States K23 AG076977 / AG / NIA NIH HHS / United States K08 NS105916 / NS / NINDS NIH HHS / United States R01AG060393 / AR / NIAMS NIH HHS / United States R24AG066599 / NH / NIH HHS / United States 890650 / / Marie Sklodowska-Curie / R01AG076018 / NH / NIH HHS / United States R56 AG083943 / AG / NIA NIH HHS / United States R01 NS118569 / NS / NINDS NIH HHS / United States 1F30AG079504-01 / AR / NIAMS NIH HHS / United States UKDRI-1011 / / UK Dementia Research Institute / R01 AG067581 / AG / NIA NIH HHS / United States / / European Union's Horizon 2020 / R01 AG076018 / AG / NIA NIH HHS / United States AL200097 / / Department of Defense / / / Rainwater Charitable Foundation / RF1NS128626 / NS / NINDS NIH HHS / United States AL230130 / / Department of Defense / RF1 NS128800 / NS / NINDS NIH HHS / United States P30 AG062677 / AG / NIA NIH HHS / United States A2021025S / / BrightFocus Foundation / / / Cure Alzheimer's Fund / K23AG076977 / NH / NIH HHS / United States P30 AG072947 / AG / NIA NIH HHS / United States R21 AG067368 / AG / NIA NIH HHS / United States AL210128 / / Department of Defense / P30 AG072947 / NH / NIH HHS / United States AARF-22-23219 / ALZ / Alzheimer's Association / United States U54AG065181 / AG / NIA NIH HHS / United States / / Glaucoma Research Foundation / 1R01AG066203-02 / NH / NIH HHS / United States T32GM007618 / AR / NIAMS NIH HHS / United States WE.03-2023-08 / / Early Career / AG083943 / NH / NIH HHS / United States RF1 AG041845 / NH / NIH HHS / United States |