Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.

TitleAdvancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.
Publication TypeJournal Article
Year of Publication2025
AuthorsKloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S, Da Mesquita S, Dabin LC, Devanand D, Duran-Laforet V, Elyaman W, Evans EE, Fitzgerald-Bocarsly P, Foley KE, Harms AS, Heneka MT, Hong S, Huang Y-WA, Jackvony S, Lai L, Le Guen Y, Lemere CA, Liddelow SA, Martin-Peña A, Orr AG, Quintana FJ, Ramey GD, Rexach JE, Rizzo SJS, Sexton C, Tang AS, Torrellas JG, Tsai AP, van Olst L, Walker KA, Wharton W, Tansey MGámez, Wilcock DM
JournalAlzheimers Dement
Volume21
Issue1
Paginatione14291
Date Published2025 Jan
ISSN1552-5279
KeywordsAlzheimer Disease, Animals, Brain, Congresses as Topic, Dementia, Humans
Abstract

The immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell-mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown to significantly contribute to Alzheimer's disease (AD) pathology, the nature and extent of immune responses in the brain in the context of AD and related dementias (ADRD) remain unclear. Furthermore, the roles of the peripheral immune system in driving ADRD pathology remain incompletely elucidated. In March of 2023, the Alzheimer's Association convened the Alzheimer's Association International Conference (AAIC), Advancements: Immunity, to discuss the roles of the immune system in ADRD. A wide range of topics were discussed, such as animal models that replicate human pathology, immune-related biomarkers and clinical trials, and lessons from other fields describing immune responses in neurodegeneration. This manuscript presents highlights from the conference and outlines avenues for future research on the roles of immunity in neurodegenerative disorders. HIGHLIGHTS: The immune system plays a central role in the pathogenesis of Alzheimer's disease. The immune system exerts numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The 2023 AAIC, Advancements: Immunity, encouraged discussions and collaborations on understanding the role of the immune system.

DOI10.1002/alz.14291
Alternate JournalAlzheimers Dement
PubMed ID39692624
PubMed Central IDPMC11772715
Grant ListT32 GM007618 / GM / NIGMS NIH HHS / United States
U19AG07486 / AG / NIA NIH HHS / United States
U54AG054345 / AG / NIA NIH HHS / United States
F30 AG079504 / AG / NIA NIH HHS / United States
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F31 AG079616 / AG / NIA NIH HHS / United States
3R01AG067581-04S1 / AG / NIA NIH HHS / United States
R01 AG066203 / AG / NIA NIH HHS / United States
/ / John Douglas French Alzheimer's Foundation /
RF1 AG080556 / AG / NIA NIH HHS / United States
U54 AG065187 / AG / NIA NIH HHS / United States
T32GM007618 / / Medical Scientist Training Program /
R01 AG053961 / AG / NIA NIH HHS / United States
R01 AG10882 / NH / NIH HHS / United States
PF-IMP-870699 / / Parkinson's Foundation /
K08 NS105916 / NH / NIH HHS / United States
RF1NS128800 / NH / NIH HHS / United States
1F31AG079616-01 / AG / NIA NIH HHS / United States
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R01 AG075802 / AG / NIA NIH HHS / United States
WE.06-2023-03 / / Alzheimer Nederland Impulssubsidie /
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K08 NS105916 / NS / NINDS NIH HHS / United States
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890650 / / Marie Sklodowska-Curie /
R01AG076018 / NH / NIH HHS / United States
R56 AG083943 / AG / NIA NIH HHS / United States
R01 NS118569 / NS / NINDS NIH HHS / United States
1F30AG079504-01 / AR / NIAMS NIH HHS / United States
UKDRI-1011 / / UK Dementia Research Institute /
R01 AG067581 / AG / NIA NIH HHS / United States
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R01 AG076018 / AG / NIA NIH HHS / United States
AL200097 / / Department of Defense /
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AL230130 / / Department of Defense /
RF1 NS128800 / NS / NINDS NIH HHS / United States
P30 AG062677 / AG / NIA NIH HHS / United States
A2021025S / / BrightFocus Foundation /
/ / Cure Alzheimer's Fund /
K23AG076977 / NH / NIH HHS / United States
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P30 AG072947 / NH / NIH HHS / United States
AARF-22-23219 / ALZ / Alzheimer's Association / United States
U54AG065181 / AG / NIA NIH HHS / United States
/ / Glaucoma Research Foundation /
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WE.03-2023-08 / / Early Career /
AG083943 / NH / NIH HHS / United States
RF1 AG041845 / NH / NIH HHS / United States