Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 200 results
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2022
Kuo S-H, Tasset I, Cheng MM, Diaz A, Pan M-K, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P et al..  2022.  Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.. Sci Adv. 8(6):eabm6393.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al..  2022.  Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al..  2022.  Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.
Blackwell DJ, Faggioni M, Wleklinski MJ, Gomez-Hurtado N, Venkataraman R, Gibbs CE, Baudenbacher FJ, Gong S, Fishman GI, Boyle PM et al..  2022.  The Purkinje-myocardial junction is the anatomical origin of ventricular arrhythmia in CPVT.. JCI Insight.
Hardwick SA, Hu W, Joglekar A, Fan L, Collier PG, Foord C, Balacco J, Lanjewar S, Sampson MMcGuirk, Koopmans F et al..  2022.  Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue.. Nat Biotechnol.
Carnazza KE, Komer LE, Xie YXue, Pineda A, Briano JAntonio, Gao V, Na Y, Ramlall T, Buchman VL, Eliezer D et al..  2022.  Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins.. Cell Rep. 39(2):110675.
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Huttenhain R, Kauwe G et al..  2022.  Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.. Cell. 185(4):712-728.e14.
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Huttenhain R, Kauwe G et al..  2022.  Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.. Cell. 185(4):712-728.e14.
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Huttenhain R, Kauwe G et al..  2022.  Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.. Cell. 185(4):712-728.e14.
Yan Y, Wang X, Chaput D, Shin M-K, Koh Y, Gan L, Pieper AA, Woo J-AA, Kang DE.  2022.  X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.. Cell. 185(21):3913-3930.e19.
Yan Y, Wang X, Chaput D, Shin M-K, Koh Y, Gan L, Pieper AA, Woo J-AA, Kang DE.  2022.  X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.. Cell. 185(21):3913-3930.e19.
2021
Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PDongmin, Chen X, Wang C, Juste YR, Wegmann S, Patel B et al..  2021.  Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.. Nat Commun. 12(1):2238.
Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PDongmin, Chen X, Wang C, Juste YR, Wegmann S, Patel B et al..  2021.  Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.. Nat Commun. 12(1):2238.
Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MYing, Horowitz R et al..  2021.  AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.. Sci Transl Med. 13(622):eabe3947.
Singh SKumar, Kumar S, Viswakarma N, Principe DR, Das S, Sondarva G, Nair RSathish, Srivastava P, Sinha SC, Grippo PJ et al..  2021.  MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3.. Oncogene. 40(43):6153-6165.
Viswakarma N, Sondarva G, Principe DR, Nair RSathish, Kumar S, Singh SKumar, Das S, Sinha SC, Grippo PJ, Grimaldo S et al..  2021.  Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development.. Cancer Lett. 515:1-13.
Shin M-K, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF et al..  2021.  Reducing acetylated tau is neuroprotective in brain injury.. Cell.
Shin M-K, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF et al..  2021.  Reducing acetylated tau is neuroprotective in brain injury.. Cell.
Shin M-K, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF et al..  2021.  Reducing acetylated tau is neuroprotective in brain injury.. Cell.
Shin M-K, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF et al..  2021.  Reducing acetylated tau is neuroprotective in brain injury.. Cell.
Lopez-Lee C, Kodama L, Gan L.  2021.  Sex Differences in Neurodegeneration: The Role of the Immune System in Humans.. Biol Psychiatry.
2020
Naseri NN, Ergel B, Kharel P, Na Y, Huang Q, Huang R, Dolzhanskaya N, Burré J, Velinov MT, Sharma M.  2020.  Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.. Nat Struct Mol Biol. 27(2):192-201.
Inda MCarmen, Joshi S, Wang T, Bolaender A, Gandu S, Iii JKoren, Che AYue, Taldone T, Yan P, Sun W et al..  2020.  The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.. Nat Commun. 11(1):319.
Zhan L, Fan L, Kodama L, Sohn PDongmin, Wong MYing, Mousa GAlzaem, Zhou Y, Li Y, Gan L.  2020.  A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain.. Elife. 9
Kumar S, Singh SKumar, Viswakarma N, Sondarva G, Nair RSathish, Sethupathi P, Sinha SC, Emmadi R, Hoskins K, Danciu O et al..  2020.  Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.. Proc Natl Acad Sci U S A. 117(14):7961-7970.