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Found 173 results
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2011
Cissé M
,
Halabisky B
,
Harris J
,
Devidze N
,
Dubal DB
,
Sun B
,
Orr A
,
Lotz G
,
Kim DH
,
Hamto P
et al.
. 2011.
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
.
Nature. 469(7328):47-52.
2010
Hansen KB
,
Mullasseril P
,
Dawit S
,
Kurtkaya NL
,
Yuan H
,
Vance KM
,
Orr AG
,
Kvist T
,
Ogden KK
,
Le P
et al.
. 2010.
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
.
J Pharmacol Exp Ther. 333(3):650-62.
Hansen KB
,
Mullasseril P
,
Dawit S
,
Kurtkaya NL
,
Yuan H
,
Vance KM
,
Orr AG
,
Kvist T
,
Ogden KK
,
Le P
et al.
. 2010.
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
.
J Pharmacol Exp Ther. 333(3):650-62.
Hansen KB
,
Mullasseril P
,
Dawit S
,
Kurtkaya NL
,
Yuan H
,
Vance KM
,
Orr AG
,
Kvist T
,
Ogden KK
,
Le P
et al.
. 2010.
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
.
J Pharmacol Exp Ther. 333(3):650-62.
Vives-Bauza C
,
Zhou C
,
Huang Y
,
Cui M
,
de Vries RLA
,
Kim J
,
May J
,
Tocilescu MAleksandra
,
Liu W
,
Ko HSeok
et al.
. 2010.
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
.
Proc Natl Acad Sci U S A. 107(1):378-83.
Vives-Bauza C
,
Zhou C
,
Huang Y
,
Cui M
,
de Vries RLA
,
Kim J
,
May J
,
Tocilescu MAleksandra
,
Liu W
,
Ko HSeok
et al.
. 2010.
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
.
Proc Natl Acad Sci U S A. 107(1):378-83.
Gong S
,
Kus L
,
Heintz N
. 2010.
Rapid bacterial artificial chromosome modification for large-scale mouse transgenesis.
.
Nat Protoc. 5(10):1678-96.
Mullasseril P
,
Hansen KB
,
Vance KM
,
Ogden KK
,
Yuan H
,
Kurtkaya NL
,
Santangelo R
,
Orr AG
,
Le P
,
Vellano KM
et al.
. 2010.
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.
.
Nat Commun. 1:90.
2009
Landon MR
,
Lieberman RL
,
Hoang QQ
,
Ju S
,
Caaveiro JMM
,
Orwig SD
,
Kozakov D
,
Brenke R
,
Chuang G-Y
,
Beglov D
et al.
. 2009.
Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.
.
J Comput Aided Mol Des. 23(8):491-500.
Bales KR
,
Liu F
,
Wu S
,
Lin S
,
Koger D
,
DeLong C
,
Hansen JC
,
Sullivan PM
,
Paul SM
. 2009.
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
.
J Neurosci. 29(21):6771-9.
Zhao L
,
Lin S
,
Bales KR
,
Gelfanova V
,
Koger D
,
DeLong C
,
Hale J
,
Liu F
,
Hunter JM
,
Paul SM
. 2009.
Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.
.
J Neurosci. 29(11):3603-12.
Kim J
,
Castellano JM
,
Jiang H
,
Basak JM
,
Parsadanian M
,
Pham V
,
Mason SM
,
Paul SM
,
Holtzman DM
. 2009.
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
.
Neuron. 64(5):632-44.
2008
Bateup HS
,
Svenningsson P
,
Kuroiwa M
,
Gong S
,
Nishi A
,
Heintz N
,
Greengard P
. 2008.
Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs.
.
Nat Neurosci. 11(8):932-9.
2007
Luo W
,
Dou F
,
Rodina A
,
Chip S
,
Kim J
,
Zhao Q
,
Moulick K
,
Aguirre J
,
Wu N
,
Greengard P
et al.
. 2007.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
.
Proc Natl Acad Sci U S A. 104(22):9511-6.
Lieberman RL
,
Wustman BA
,
Huertas P
,
Powe AC
,
Pine CW
,
Khanna R
,
Schlossmacher MG
,
Ringe D
,
Petsko GA
. 2007.
Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
.
Nat Chem Biol. 3(2):101-7.
2006
Burré J
,
Beckhaus T
,
Schägger H
,
Corvey C
,
Hofmann S
,
Karas M
,
Zimmermann H
,
Volknandt W
. 2006.
Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques.
.
Proteomics. 6(23):6250-62.
Das C
,
Hoang QQ
,
Kreinbring CA
,
Luchansky SJ
,
Meray RK
,
Ray SS
,
Lansbury PT
,
Ringe D
,
Petsko GA
. 2006.
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
.
Proc Natl Acad Sci U S A. 103(12):4675-80.
Burré J
,
Beckhaus T
,
Corvey C
,
Karas M
,
Zimmermann H
,
Volknandt W
. 2006.
Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis.
.
Electrophoresis. 27(17):3488-96.
2005
Brendza RP
,
Bacskai BJ
,
Cirrito JR
,
Simmons KA
,
Skoch JM
,
Klunk WE
,
Mathis CA
,
Bales KR
,
Paul SM
,
Hyman BT
et al.
. 2005.
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
.
J Clin Invest. 115(2):428-33.
Dodart J-C
,
Marr RA
,
Koistinaho M
,
Gregersen BM
,
Malkani S
,
Verma IM
,
Paul SM
. 2005.
Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.
.
Proc Natl Acad Sci U S A. 102(4):1211-6.
Morciano M
,
Burré J
,
Corvey C
,
Karas M
,
Zimmermann H
,
Volknandt W
. 2005.
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
.
J Neurochem. 95(6):1732-45.
Beilina A
,
Van Der Brug M
,
Ahmad R
,
Kesavapany S
,
Miller DW
,
Petsko GA
,
Cookson MR
. 2005.
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.
.
Proc Natl Acad Sci U S A. 102(16):5703-8.
Kaczmarek LK
,
Bhattacharjee A
,
Desai R
,
Gan L
,
Song P
,
von Hehn CAA
,
Whim MD
,
Yang B
. 2005.
Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.
.
Hear Res. 206(1-2):133-45.
Chen J
,
Zhou Y
,
Mueller-Steiner S
,
Chen L-F
,
Kwon H
,
Yi S
,
Mucke L
,
Gan L
. 2005.
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
.
J Biol Chem. 280(48):40364-74.
2004
Koistinaho M
,
Lin S
,
Wu X
,
Esterman M
,
Koger D
,
Hanson J
,
Higgs R
,
Liu F
,
Malkani S
,
Bales KR
et al.
. 2004.
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.
.
Nat Med. 10(7):719-26.
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