Current mouse and cell models in prostate cancer research.

TitleCurrent mouse and cell models in prostate cancer research.
Publication TypeJournal Article
Year of Publication2013
AuthorsWu X, Gong S, Roy-Burman P, Lee P, Culig Z
JournalEndocr Relat Cancer
Date Published2013 Aug
KeywordsAnimals, Biomedical Research, Cell Line, Tumor, Disease Models, Animal, Humans, Male, Mice, Mice, Transgenic, Prostatic Neoplasms, Stem Cells, Xenograft Model Antitumor Assays

Mouse models of prostate cancer (PCa) are critical for understanding the biology of PCa initiation, progression, and treatment modalities. Here, we summarize recent advances in PCa mouse models that led to new insights into specific gene functions in PCa. For example, the study of transgenic mice with TMPRSS2/ERG, an androgen-regulated fusion protein, revealed its role in developing PCa precursor lesions, prostate intraepithelial neoplasia; however, it is not sufficient for PCa development. Double deficiency of Pten and Smad4 leads to a high incidence of metastatic PCa. Targeted deletion of Pten in castration-resistant Nkx3-1-expressing cells results in rapid carcinoma formation after androgen-mediated regeneration, indicating that progenitor cells with luminal characteristics can play a role in initiation of PCa. Transgenic mice with activated oncogenes, growth factors, and steroid hormone receptors or inactivated tumor suppressors continue to provide insights into disease progression from initiation to metastasis. Further development of new PCa models with spatial and temporal regulation of candidate gene expression will probably enhance our understanding of the complex events that lead to PCa initiation and progression, thereby invoking novel strategies to combat this common disease in men.

Alternate JournalEndocr. Relat. Cancer
PubMed ID23580590
PubMed Central IDPMC3855867
Grant ListR01 CA059705 / CA / NCI NIH HHS / United States
U01 CA149556 / CA / NCI NIH HHS / United States
1U01CA149556-01 / CA / NCI NIH HHS / United States
R01CA59705 / CA / NCI NIH HHS / United States