Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.

TitleEndo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.
Publication TypeJournal Article
Year of Publication2018
AuthorsWang C, Telpoukhovskaia MA, Bahr BA, Chen X, Gan L
JournalCurr Opin Neurobiol
Date Published2018 02

Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia (FTD). Mutations of these genes lead to dysfunction in multiple steps of the endo-lysosomal network: autophagy, endocytic trafficking and lysosomal degradation, resulting in accumulation of pathogenic proteins. Although the exact pathogenic mechanism varies for different disease-associated genes, dysfunction of the endo-lysosomal pathways represents a converging mechanism shared by these diseases. Therefore, strategies that correct or compensate for endo-lysosomal dysfunction may be promising therapeutic approaches to treat neurodegenerative diseases.

Alternate JournalCurr. Opin. Neurobiol.
PubMed ID29028540
Grant ListR01 AG051390 / AG / NIA NIH HHS / United States
U54 NS100717 / NS / NINDS NIH HHS / United States
K99 AG053439 / AG / NIA NIH HHS / United States