Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 410 results

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2024

Bravo CParra, Giani AMaria, Madero-Pérez J, Zhao Z, Wan Y, Samelson AJ, Wong MYing, Evangelisti A, Cordes E, Fan L et al.. 2024. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. Cell. 187(10):2446-2464.e22.

Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y et al.. 2024. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. J Clin Invest. 134(3)

Zheng X, Wu B, Liu Y, Simmons SK, Kim K, Clarke GS, Ashiq A, Park J, Li J, Wang Z et al.. 2024. Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development.. Cell. 187(13):3236-3248.e21.

Lopez-Lee C, Torres ERuth S, Carling G, Gan L. 2024. Mechanisms of sex differences in Alzheimer's disease.. Neuron.

Hanzel M, Fernando K, Maloney SE, Horn Z, Gong S, Mätlik K, Zhao J, H Pasolli A, Heissel S, Dougherty JD et al.. 2024. Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties.. Proc Natl Acad Sci U S A. 121(34):e2405901121.

Wang C, Zhao C, Hu X, Qiang J, Liu Z, Gu J, Zhang S, Li D, Zhang Y, Burré J et al.. 2024. N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine.. bioRxiv.

Kong W, Frouard J, Xie G, Corley MJ, Helmy E, Zhang G, Schwarzer R, Montano M, Sohn P, Roan NR et al.. 2024. Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids.. PNAS Nexus. 3(5):pgae179.

Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al.. 2024. Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.. Nat Commun. 15(1):10269.

Fridy PC, Farrell RJ, Molloy KR, Keegan S, Wang J, Jacobs EY, Li Y, Trivedi J, Sehgal V, Fenyö D et al.. 2024. A new generation of nanobody research tools using improved mass spectrometry-based discovery methods.. J Biol Chem. 300(9):107623.

Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al.. 2024. Novel avenues of tau research.. Alzheimers Dement.

Wallace CH, Oliveros G, Xie L, Serrano P, Rockwell P, Figueiredo-Pereira M. 2024. Potential Alzheimer's early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathology.. Sci Rep. 14(1):3730.

Bustos VHugo, Sunkari YKrishna, Sinha A, Pulina M, Bispo A, Hopkins M, Lam A, Kriegsman SF, Mui E, Chang E et al.. 2024. Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels.. ACS Chem Biol. 19(1):37-47.

Burré J, Edwards RH, Halliday G, Lang AE, Lashuel HA, Melki R, Murayama S, Outeiro TF, Papa SM, Stefanis L et al.. 2024. Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis.. Mov Disord. 39(10):1663-1678.

Netzer WJ, Sinha A, Ghias M, Chang E, Gindinova K, Mui E, Seo J-S, Sinha SC. 2024. Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP.. Front Chem. 12:1381205.

Bennett NK, Lee M, Orr AL, Nakamura K. 2024. Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.. Proc Natl Acad Sci U S A. 121(3):e2307904121.

Lopez-Lee C, Kodama L, Fan L, Zhu D, Zhu J, Wong MYing, Ye P, Norman K, Foxe NR, Ijaz L et al.. 2024. Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination.. Science. 386(6725):eadk7844.

Wang C, Zhang K, Cai B, Haller JE, Carnazza KE, Hu J, Zhao C, Tian Z, Hu X, Hall D et al.. 2024. VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates.. Nat Cell Biol. 26(8):1287-1295.

2023

Luo W, Qu W, Gan L. 2023. The AD odyssey 2023: Tales of single cell.. Cell. 186(20):4257-4259.

Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu G-Q, Yu X, Smith N et al.. 2023. Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.. Neurobiol Dis. 186:106263.

Barnett D, Bohmbach K, Grelot V, Charlet A, Dallérac G, Ju YHa, Nagai J, Orr AG. 2023. Astrocytes as Drivers and Disruptors of Behavior: New Advances in Basic Mechanisms and Therapeutic Targeting.. J Neurosci. 43(45):7463-7471.

Licht-Murava A, Meadows SM, Palaguachi F, Song SC, Jackvony S, Bram Y, Zhou C, Schwartz RE, Froemke RC, Orr AL et al.. 2023. Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.. Sci Adv. 9(16):eade1282.

Amin S, Liu B, Gan L. 2023. Autophagy prevents microglial senescence.. Nat Cell Biol. 25(7):923-925.

Uekawa K, Hattori Y, Ahn SJi, Seo J, Casey N, Anfray A, Zhou P, Luo W, Anrather J, Park L et al.. 2023. Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress.. Mol Neurodegener. 18(1):73.

Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CParra, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D et al.. 2023. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.. bioRxiv.

Chen H, Fan L, Guo Q, Wong MYing, Yu F, Foxe N, Wang W, Nessim A, Carling G, Liu B et al.. 2023. DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.. Res Sq.