Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 120 results
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2024
Iannone AF, Akgül G, Zhang R, Wacks S, Hussein N, Macias CGinelly, Donatelle A, Bauriedel JMJ, Wright C, Abramov D et al..  2024.  The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex.. Cell Rep. 43(8):114531.
Iannone AF, Akgül G, Zhang R, Wacks S, Hussein N, Macias CGinelly, Donatelle A, Bauriedel JMJ, Wright C, Abramov D et al..  2024.  The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex.. Cell Rep. 43(8):114531.
Guiberson NGuy Lewis, Black LS, Haller JE, Brukner A, Abramov D, Ahmad S, Xie YXin, Sharma M, Burré J.  2024.  Disease-linked mutations in Munc18-1 deplete synaptic Doc2.. Brain.
Guiberson NGuy Lewis, Black LS, Haller JE, Brukner A, Abramov D, Ahmad S, Xie YXin, Sharma M, Burré J.  2024.  Disease-linked mutations in Munc18-1 deplete synaptic Doc2.. Brain.
Oostrom M, Muniak MA, West RMEichler, Akers S, Pande P, Obiri M, Wang W, Bowyer K, Wu Z, Bramer LM et al..  2024.  Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images.. PLoS One. 19(3):e0293856.
Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R et al..  2024.  iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.. Mol Cell Neurosci. 130:103954.
Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R et al..  2024.  iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.. Mol Cell Neurosci. 130:103954.
Zheng X, Wu B, Liu Y, Simmons SK, Kim K, Clarke GS, Ashiq A, Park J, Li J, Wang Z et al..  2024.  Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development.. Cell. 187(13):3236-3248.e21.
Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al..  2024.  Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.. Nat Commun. 15(1):10269.
2023
Amin S, Liu B, Gan L.  2023.  Autophagy prevents microglial senescence.. Nat Cell Biol. 25(7):923-925.
Uekawa K, Hattori Y, Ahn SJi, Seo J, Casey N, Anfray A, Zhou P, Luo W, Anrather J, Park L et al..  2023.  Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress.. Mol Neurodegener. 18(1):73.
Uekawa K, Hattori Y, Ahn SJi, Seo J, Casey N, Anfray A, Zhou P, Luo W, Anrather J, Park L et al..  2023.  Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress.. Mol Neurodegener. 18(1):73.
Uekawa K, Hattori Y, Ahn SJi, Seo J, Casey N, Anfray A, Zhou P, Luo W, Anrather J, Park L et al..  2023.  Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress.. Mol Neurodegener. 18(1):73.
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CParra, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D et al..  2023.  CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.. bioRxiv.
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CParra, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D et al..  2023.  CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.. bioRxiv.
Chen H, Fan L, Guo Q, Wong MYing, Yu F, Foxe N, Wang W, Nessim A, Carling G, Liu B et al..  2023.  DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.. Res Sq.
Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al..  2023.  Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.. Res Sq.
Huang Y, Liu B, Sinha SC, Amin S, Gan L.  2023.  Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders.. Mol Neurodegener. 18(1):79.
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERuth S, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G et al..  2023.  Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.. Nat Neurosci. 26(5):737-750.
2022
Dräger NM, Sattler SM, Huang CTzu-Ling, Teter OM, Leng K, Hashemi SHadi, Hong J, Aviles G, Clelland CD, Zhan L et al..  2022.  A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.. Nat Neurosci.
Cai T, Abbu KAlyssa, Liu Y, Xie L.  2022.  DeepREAL: a deep learning powered multi-scale modeling framework for predicting out-of-distribution ligand-induced GPCR activity.. Bioinformatics. 38(9):2561-2570.
Kuo S-H, Tasset I, Cheng MM, Diaz A, Pan M-K, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P et al..  2022.  Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.. Sci Adv. 8(6):eabm6393.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al..  2022.  Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.
2021
Amin S, Carling G, Gan L.  2021.  New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.. Curr Opin Neurobiol. 72:131-139.
Shin M-K, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF et al..  2021.  Reducing acetylated tau is neuroprotective in brain injury.. Cell.