Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 106 results
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2023
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CParra, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D et al..  2023.  CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.. bioRxiv.
Chen H, Fan L, Guo Q, Wong MYing, Yu F, Foxe N, Wang W, Nessim A, Carling G, Liu B et al..  2023.  DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.. Res Sq.
Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al..  2023.  Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.. Res Sq.
Huang Y, Liu B, Sinha SC, Amin S, Gan L.  2023.  Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders.. Mol Neurodegener. 18(1):79.
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERuth S, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G et al..  2023.  Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.. Nat Neurosci. 26(5):737-750.
2022
Dräger NM, Sattler SM, Huang CTzu-Ling, Teter OM, Leng K, Hashemi SHadi, Hong J, Aviles G, Clelland CD, Zhan L et al..  2022.  A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.. Nat Neurosci.
Cai T, Abbu KAlyssa, Liu Y, Xie L.  2022.  DeepREAL: a deep learning powered multi-scale modeling framework for predicting out-of-distribution ligand-induced GPCR activity.. Bioinformatics. 38(9):2561-2570.
Kuo S-H, Tasset I, Cheng MM, Diaz A, Pan M-K, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P et al..  2022.  Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.. Sci Adv. 8(6):eabm6393.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al..  2022.  Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.
2021
Amin S, Carling G, Gan L.  2021.  New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.. Curr Opin Neurobiol. 72:131-139.
Shin M-K, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF et al..  2021.  Reducing acetylated tau is neuroprotective in brain injury.. Cell.
Shin M-K, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF et al..  2021.  Reducing acetylated tau is neuroprotective in brain injury.. Cell.
2020
Wong MYing, Lewis M, Doherty JJ, Shi Y, Cashikar AG, Amelianchik A, Tymchuk S, Sullivan PM, Qian M, Covey DF et al..  2020.  25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.. J Neuroinflammation. 17(1):192.
Limbad C, Oron TRonnen, Alimirah F, Davalos AR, Tracy TE, Gan L, Desprez P-Y, Campisi J.  2020.  Astrocyte senescence promotes glutamate toxicity in cortical neurons.. PLoS One. 15(1):e0227887.
Acosta-Ruiz A, Gutzeit VA, Skelly MJane, Meadows S, Lee J, Parekh P, Orr AG, Liston C, Pleil KE, Broichhagen J et al..  2020.  Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo.. Neuron. 105(3):446-463.e13.
Inda MCarmen, Joshi S, Wang T, Bolaender A, Gandu S, Iii JKoren, Che AYue, Taldone T, Yan P, Sun W et al..  2020.  The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.. Nat Commun. 11(1):319.
Zhu PK, W Zheng S, Zhang P, Jing M, Borden PM, Ali F, Guo K, Feng J, Marvin JS, Wang Y et al..  2020.  Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors.. Nano Lett. 20(6):4073-4083.
Chen X, Li Y, Wang C, Tang Y, Mok S-A, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL et al..  2020.  Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.. Mol Neurodegener. 15(1):2.
Abramov D, Guiberson NGuy Lewis, Burré J.  2020.  STXBP1 encephalopathies: Clinical spectrum, disease mechanisms, and therapeutic strategies.. J Neurochem.
Abramov D, Guiberson NGuy Lewis, Daab A, Na Y, Petsko GA, Sharma M, Burré J.  2020.  Targeted stabilization of Munc18-1 function via pharmacological chaperones.. EMBO Mol Med. :e12354.
2019
Ayed M, Lim H, Xie L.  2019.  Biological representation of chemicals using latent target interaction profile.. BMC Bioinformatics. 20(Suppl 24):674.
Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PDongmin, Bowles KR et al..  2019.  A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.. Stem Cell Reports.
Sohn PDongmin, Huang CTzu-Ling, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok S-A, Freilich R et al..  2019.  Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.. Neuron.
2018
Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C et al..  2018.  Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.. Proc Natl Acad Sci U S A. 115(40):10172-10177.
Guiberson NGuy Lewis, Pineda A, Abramov D, Kharel P, Carnazza KE, Wragg RT, Dittman JS, Burré J.  2018.  Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones.. Nat Commun. 9(1):3986.