Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 306 results
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2004
Koistinaho M, Lin S, Wu X, Esterman M, Koger D, Hanson J, Higgs R, Liu F, Malkani S, Bales KR et al..  2004.  Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.. Nat Med. 10(7):719-26.
Liang Y, Lin S, Beyer TP, Zhang Y, Wu X, Bales KR, DeMattos RB, May PC, Li SDan, Jiang X-C et al..  2004.  A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.. J Neurochem. 88(3):623-34.
Liang Y, Lin S, Beyer TP, Zhang Y, Wu X, Bales KR, DeMattos RB, May PC, Li SDan, Jiang X-C et al..  2004.  A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.. J Neurochem. 88(3):623-34.
Sharma M, Pampinella F, Nemes C, Benharouga M, So J, Du K, Bache KG, Papsin B, Zerangue N, Stenmark H et al..  2004.  Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.. J Cell Biol. 164(6):923-33.
Sharma M, Pampinella F, Nemes C, Benharouga M, So J, Du K, Bache KG, Papsin B, Zerangue N, Stenmark H et al..  2004.  Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.. J Cell Biol. 164(6):923-33.
Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR.  2004.  The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.. Proc Natl Acad Sci U S A. 101(24):9103-8.
Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR.  2004.  The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.. Proc Natl Acad Sci U S A. 101(24):9103-8.
2003
Benharouga M, Sharma M, So J, Haardt M, Drzymala L, Popov M, Schwapach B, Grinstein S, Du K, Lukacs GL.  2003.  The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia.. J Biol Chem. 278(24):22079-89.
2002
DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM.  2002.  Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.. Science. 295(5563):2264-7.
Benharouga M, Sharma M, Lukacs GL.  2002.  CFTR folding and maturation in cells.. Methods Mol Med. 70:229-43.
DeMattos RB, O'dell MA, Parsadanian M, Taylor JW, Harmony JAK, Bales KR, Paul SM, Aronow BJ, Holtzman DM.  2002.  Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 99(16):10843-8.
Fagan AM, Watson M, Parsadanian M, Bales KR, Paul SM, Holtzman DM.  2002.  Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.. Neurobiol Dis. 9(3):305-18.
Dodart J-C, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM et al..  2002.  Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.. Nat Neurosci. 5(5):452-7.
Bhattacharjee A, Gan L, Kaczmarek LK.  2002.  Localization of the Slack potassium channel in the rat central nervous system.. J Comp Neurol. 454(3):241-54.
2001
Sharma M, Benharouga M, Hu W, Lukacs GL.  2001.  Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.. J Biol Chem. 276(12):8942-50.
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM.  2001.  Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 98(15):8850-5.
2000
Holtzman DM, Bales KR, Tenkova T, Fagan AM, Parsadanian M, Sartorius LJ, Mackey B, Olney J, McKeel D, Wozniak D et al..  2000.  Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 97(6):2892-7.
Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG.  2000.  The catalytic pathway of cytochrome p450cam at atomic resolution.. Science. 287(5458):1615-22.
Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG.  2000.  The catalytic pathway of cytochrome p450cam at atomic resolution.. Science. 287(5458):1615-22.
Bales KR, Du Y, Holtzman D, Cordell B, Paul SM.  2000.  Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E.. Neurobiol Aging. 21(3):427-32;discussion451-3.
Heymont J, Berenfeld L, Collins J, Kaganovich A, Maynes B, Moulin A, Ratskovskaya I, Poon PP, Johnston GC, Kamenetsky M et al..  2000.  TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation.. Proc Natl Acad Sci U S A. 97(23):12672-7.
1999
Bales KR, Verina T, Cummins DJ, Du Y, Dodel RC, Saura J, Fishman CE, DeLong CA, Piccardo P, Petegnief V et al..  1999.  Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 96(26):15233-8.
Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM.  1999.  Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.. J Clin Invest. 103(6):R15-R21.
Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM.  1999.  Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.. J Clin Invest. 103(6):R15-R21.
1998
Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK.  1998.  Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.. Nat Neurosci. 1(6):462-9.