Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 236 results

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1997

Bodick NC, Offen WW, Levey AI, Cutler NR, Gauthier SG, Satlin A, Shannon HE, Tollefson GD, Rasmussen K, Bymaster FP et al.. 1997. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.. Arch Neurol. 54(4):465-73.

Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ et al.. 1997. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.. Nat Genet. 17(3):263-4.

1998

Ginns EI, St Jean P, Philibert RA, Galdzicka M, Damschroder-Williams P, Thiel B, Long RT, Ingraham LJ, Dalwaldi H, Murray MA et al.. 1998. A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish.. Proc Natl Acad Sci U S A. 95(26):15531-6.

1999

Bales KR, Verina T, Cummins DJ, Du Y, Dodel RC, Saura J, Fishman CE, DeLong CA, Piccardo P, Petegnief V et al.. 1999. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 96(26):15233-8.

Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM. 1999. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.. J Clin Invest. 103(6):R15-R21.

2000

Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG. 2000. The catalytic pathway of cytochrome p450cam at atomic resolution.. Science. 287(5458):1615-22.

Bales KR, Du Y, Holtzman D, Cordell B, Paul SM. 2000. Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E.. Neurobiol Aging. 21(3):427-32;discussion451-3.

Heymont J, Berenfeld L, Collins J, Kaganovich A, Maynes B, Moulin A, Ratskovskaya I, Poon PP, Johnston GC, Kamenetsky M et al.. 2000. TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation.. Proc Natl Acad Sci U S A. 97(23):12672-7.

2001

DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. 2001. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 98(15):8850-5.

Rho J, Gong S, Kim N, Choi Y. 2001. TDAG51 is not essential for Fas/CD95 regulation and apoptosis in vivo.. Mol Cell Biol. 21(24):8365-70.

2002

DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM. 2002. Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.. Science. 295(5563):2264-7.

2004

DeMattos RB, Cirrito JR, Parsadanian M, May PC, O'dell MA, Taylor JW, Harmony JAK, Aronow BJ, Bales KR, Paul SM et al.. 2004. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.. Neuron. 41(2):193-202.

Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S et al.. 2004. Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.. J Biol Chem. 279(7):5565-72.

Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S et al.. 2004. Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.. J Biol Chem. 279(7):5565-72.

Liang Y, Lin S, Beyer TP, Zhang Y, Wu X, Bales KR, DeMattos RB, May PC, Li SDan, Jiang X-C et al.. 2004. A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.. J Neurochem. 88(3):623-34.

Gresch O, Engel FB, Nesic D, Tran TThai, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S et al.. 2004. New non-viral method for gene transfer into primary cells.. Methods. 33(2):151-63.

Gresch O, Engel FB, Nesic D, Tran TThai, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S et al.. 2004. New non-viral method for gene transfer into primary cells.. Methods. 33(2):151-63.

Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR. 2004. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.. Proc Natl Acad Sci U S A. 101(24):9103-8.

Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR. 2004. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.. Proc Natl Acad Sci U S A. 101(24):9103-8.

2005

Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT et al.. 2005. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.. J Clin Invest. 115(2):428-33.

Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W. 2005. Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.. J Neurochem. 95(6):1732-45.

Beilina A, Van Der Brug M, Ahmad R, Kesavapany S, Miller DW, Petsko GA, Cookson MR. 2005. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.. Proc Natl Acad Sci U S A. 102(16):5703-8.

Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CAF, Breiderhoff T, Jansen P, Wu X et al.. 2005. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.. Proc Natl Acad Sci U S A. 102(38):13461-6.

Chen J, Zhou Y, Mueller-Steiner S, Chen L-F, Kwon H, Yi S, Mucke L, Gan L. 2005. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.. J Biol Chem. 280(48):40364-74.

Chen J, Zhou Y, Mueller-Steiner S, Chen L-F, Kwon H, Yi S, Mucke L, Gan L. 2005. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.. J Biol Chem. 280(48):40364-74.