Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 157 results
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2015
Min S-W, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, S Minami S, Defensor E, Mok SAnn et al..  2015.  Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.. Nat Med. 21(10):1154-62.
S Minami S, Shen V, Le D, Krabbe G, Asgarov R, Perez-Celajes L, Lee C-H, Li J, Donnelly-Roberts D, Gan L.  2015.  Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.. Biochem Pharmacol. 97(4):454-462.
Cho S-H, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PDongmin, Lo I, Minami S et al..  2015.  SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.. J Neurosci. 35(2):807-18.
Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RLS et al..  2015.  Suppressors of superoxide production from mitochondrial complex III.. Nat Chem Biol. 11(11):834-6.
Kim KHye, Liu J, Galvin RJSells, Dage JL, Egeland JA, Smith RC, Merchant KM, Paul SM.  2015.  Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree.. PLoS One. 10(11):e0142693.
2014
Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M et al..  2014.  2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.. Alzheimers Dement. 10(5 Suppl):S430-52.
Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M et al..  2014.  2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.. Alzheimers Dement. 10(5 Suppl):S430-52.
Auclair JR, Salisbury JP, Johnson JL, Petsko GA, Ringe D, Bosco DA, Agar NYR, Santagata S, Durham HD, Agar JN.  2014.  Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.. Proteomics. 14(10):1152-7.
McKnight NC, Zhong Y, Wold MS, Gong S, Phillips GR, Dou Z, Zhao Y, Heintz N, Zong W-X, Yue Z.  2014.  Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.. PLoS Genet. 10(10):e1004626.
Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S.  2014.  Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.. Neuropharmacology. 85:232-42.
2013
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.. Mol Psychiatry. 18(8):889-97.
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.. Mol Psychiatry. 18(8):889-97.
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.. Mol Psychiatry. 18(8):882-8.
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.. Mol Psychiatry. 18(8):882-8.
Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu H-J, Izumi Y et al..  2013.  The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.. J Neurosci. 33(44):17290-300.
Diao J, Burré J, Vivona S, Cipriano DJ, Sharma M, Kyoung M, Südhof TC, Brunger AT.  2013.  Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.. Elife. 2:e00592.
Pranski E, Van Sanford CD, Dalal N, Orr AL, Karmali D, Cooper DS, Gearing M, Lah JJ, Levey AI, Betarbet R.  2013.  NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease.. Neurosci Lett. 547:16-20.
Burré J, Vivona S, Diao J, Sharma M, Brunger AT, Südhof TC.  2013.  Properties of native brain α-synuclein.. Nature. 498(7453):E4-6;discussionE6-7.
Auclair JR, Brodkin HR, J D'Aquino A, Petsko GA, Ringe D, Agar JN.  2013.  Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase.. Biochemistry. 52(36):6145-50.
2012
Davies CW, Chaney J, Korbel G, Ringe D, Petsko GA, Ploegh H, Das C.  2012.  The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).. Bioorg Med Chem Lett. 22(12):3900-4.
Davies CW, Chaney J, Korbel G, Ringe D, Petsko GA, Ploegh H, Das C.  2012.  The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).. Bioorg Med Chem Lett. 22(12):3900-4.
Pranski EL, Van Sanford CD, Dalal NV, Orr AL, Karmali D, Cooper DS, Costa N, Heilman CJ, Gearing M, Lah JJ et al..  2012.  Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.. Neurosci Lett. 520(1):104-9.
Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, DeLong C, Lin S, Zhao L et al..  2012.  Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.. Brain Res. 1467:120-32.
Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu G-Q, Palop JJ et al..  2012.  Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.. Proc Natl Acad Sci U S A. 109(42):E2895-903.
Pranski EL, Dalal NV, Herskowitz JH, Orr AL, Roesch LA, Fritz JJ, Heilman C, Lah JJ, Levey AI, Betarbet RS.  2012.  Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.. J Neuroinflammation. 9:67.