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NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease.

TitleNF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease.
Publication TypeJournal Article
Year of Publication2013
AuthorsPranski E, Van Sanford CD, Dalal N, Orr AL, Karmali D, Cooper DS, Gearing M, Lah JJ, Levey AI, Betarbet R
JournalNeurosci Lett
Volume547
Pagination16-20
Date Published2013 Jun 28
ISSN1872-7972
KeywordsBrain, Carrier Proteins, Fluorescent Antibody Technique, Humans, NF-kappa B, Parkinson Disease
Abstract

RING finger protein 11 (RNF11), a negative regulator of NF-κB signaling pathway, colocalizes with α-synuclein and is sequestered in Lewy bodies in Parkinson's disease (PD). Since persistent NF-κB activation is reported in PD, in this report we investigated if RNF11 expression level is correlated to activated NF-κB in PD. We examined RNF11 expression levels in correlation to phospho-p65, a marker for activated NF-κB, in control and PD brain tissue from cerebral cortex. In addition we performed double immunofluorescence labeling experiments to confirm this correlation. Our investigations demonstrated that the neuronal RNF11 expression was down-regulated in PD and was usually associated with increased expression of phospho-p65. Double labeling confirmed that loss of neuronal RNF11 was linked to increased phospho-p65 expression, suggesting that persistent presence of NF-κB activation could be due to decreased levels of its negative regulator. Our data exemplifies the relevance of RNF11 and persistent NF-κB activation in PD.

DOI10.1016/j.neulet.2013.04.056
Alternate JournalNeurosci. Lett.
PubMed ID23669642
PubMed Central IDPMC3699785
Grant ListP30NS055077 / NS / NINDS NIH HHS / United States
R01 ES015777 / ES / NIEHS NIH HHS / United States
ES012870 / ES / NIEHS NIH HHS / United States
T32 ES012870 / ES / NIEHS NIH HHS / United States
ES015777 / ES / NIEHS NIH HHS / United States
AG025688 / AG / NIA NIH HHS / United States
P50 AG025688 / AG / NIA NIH HHS / United States
T32 NS007480 / NS / NINDS NIH HHS / United States
NS007480 / NS / NINDS NIH HHS / United States
P30 NS055077 / NS / NINDS NIH HHS / United States