Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 113 results
Author Title Type [ Year(Asc)]
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2017
Krabbe G, S Minami S, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC et al..  2017.  Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.. Proc Natl Acad Sci U S A. 114(19):5029-5034.
2016
Faraco G, Park L, Zhou P, Luo W, Paul SM, Anrather J, Iadecola C.  2016.  Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP.. J Cereb Blood Flow Metab. 36(1):241-52.
Bettayeb K, Chang JC, Luo W, Aryal S, Varotsis D, Randolph L, Netzer WJ, Greengard P, Flajolet M.  2016.  δ-COP modulates Aβ peptide formation via retrograde trafficking of APP.. Proc Natl Acad Sci U S A. 113(19):5412-7.
2014
Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M et al..  2014.  2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.. Alzheimers Dement. 10(5 Suppl):S430-52.
Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M et al..  2014.  2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.. Alzheimers Dement. 10(5 Suppl):S430-52.
Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LHerl, Seeley WW et al..  2014.  Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.. J Exp Med. 211(10):1937-45.
Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LHerl, Seeley WW et al..  2014.  Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.. J Exp Med. 211(10):1937-45.
Choi DW, Armitage R, Brady LS, Coetzee T, Fisher W, Hyman S, Pande A, Paul S, Potter W, Roin B et al..  2014.  Medicines for the mind: policy-based "pull" incentives for creating breakthrough CNS drugs.. Neuron. 84(3):554-63.
Strauss KA, Markx S, Georgi B, Paul SM, Jinks RN, Hoshi T, McDonald A, First MB, Liu W, Benkert AR et al..  2014.  A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder.. Hum Mol Genet. 23(23):6395-406.
S Minami S, Min S-W, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME et al..  2014.  Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.. Nat Med. 20(10):1157-64.
Kreinbring CA, Remillard SP, Hubbard P, Brodkin HR, Leeper FJ, Hawksley D, Lai EY, Fulton C, Petsko GA, Ringe D.  2014.  Structure of a eukaryotic thiaminase I.. Proc Natl Acad Sci U S A. 111(1):137-42.
2013
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.. Mol Psychiatry. 18(8):889-97.
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.. Mol Psychiatry. 18(8):889-97.
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.. Mol Psychiatry. 18(8):882-8.
Liu CFeng, Liu D, Momb J, Thomas PW, Lajoie A, Petsko GA, Fast W, Ringe D.  2013.  A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.. Biochemistry. 52(9):1603-10.
Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JMM, Pybus B, Ringe D, Petsko GA, Boxer SG et al..  2013.  Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.. Proc Natl Acad Sci U S A. 110(28):E2552-61.
Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JMM, Pybus B, Ringe D, Petsko GA, Boxer SG et al..  2013.  Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.. Proc Natl Acad Sci U S A. 110(28):E2552-61.
Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JMM, Pybus B, Ringe D, Petsko GA, Boxer SG et al..  2013.  Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.. Proc Natl Acad Sci U S A. 110(28):E2552-61.
2012
Pranski EL, Dalal NV, Herskowitz JH, Orr AL, Roesch LA, Fritz JJ, Heilman C, Lah JJ, Levey AI, Betarbet RS.  2012.  Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.. J Neuroinflammation. 9:67.
Martens LHerl, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min S-W, Gan L, Finkbeiner S, Huang EJ et al..  2012.  Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.. J Clin Invest. 122(11):3955-9.
Martens LHerl, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min S-W, Gan L, Finkbeiner S, Huang EJ et al..  2012.  Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.. J Clin Invest. 122(11):3955-9.
S Minami S, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T et al..  2012.  Selective targeting of microglia by quantum dots.. J Neuroinflammation. 9:22.
2011
Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C et al..  2011.  Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.. Sci Transl Med. 3(89):89ra57.
2010
He G, Luo W, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP et al..  2010.  Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.. Nature. 467(7311):95-8.
Siemers ER, Friedrich S, Dean RA, Gonzales CR, Farlow MR, Paul SM, DeMattos RB.  2010.  Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.. Clin Neuropharmacol. 33(2):67-73.