Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 213 results

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2009

Zhao L, Lin S, Bales KR, Gelfanova V, Koger D, DeLong C, Hale J, Liu F, Hunter JM, Paul SM. 2009. Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.. J Neurosci. 29(11):3603-12.

Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM. 2009. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.. Neuron. 64(5):632-44.

2008

Bateup HS, Svenningsson P, Kuroiwa M, Gong S, Nishi A, Heintz N, Greengard P. 2008. Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs.. Nat Neurosci. 11(8):932-9.

2007

Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P et al.. 2007. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.. Proc Natl Acad Sci U S A. 104(22):9511-6.

Lieberman RL, Wustman BA, Huertas P, Powe AC, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA. 2007. Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.. Nat Chem Biol. 3(2):101-7.

2006

Burré J, Beckhaus T, Schägger H, Corvey C, Hofmann S, Karas M, Zimmermann H, Volknandt W. 2006. Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques.. Proteomics. 6(23):6250-62.

Das C, Hoang QQ, Kreinbring CA, Luchansky SJ, Meray RK, Ray SS, Lansbury PT, Ringe D, Petsko GA. 2006. Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.. Proc Natl Acad Sci U S A. 103(12):4675-80.

Burré J, Beckhaus T, Corvey C, Karas M, Zimmermann H, Volknandt W. 2006. Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis.. Electrophoresis. 27(17):3488-96.

2005

Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT et al.. 2005. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.. J Clin Invest. 115(2):428-33.

Dodart J-C, Marr RA, Koistinaho M, Gregersen BM, Malkani S, Verma IM, Paul SM. 2005. Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 102(4):1211-6.

Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W. 2005. Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.. J Neurochem. 95(6):1732-45.

Beilina A, Van Der Brug M, Ahmad R, Kesavapany S, Miller DW, Petsko GA, Cookson MR. 2005. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.. Proc Natl Acad Sci U S A. 102(16):5703-8.

Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CAA, Whim MD, Yang B. 2005. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.. Hear Res. 206(1-2):133-45.

Chen J, Zhou Y, Mueller-Steiner S, Chen L-F, Kwon H, Yi S, Mucke L, Gan L. 2005. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.. J Biol Chem. 280(48):40364-74.

2004

Koistinaho M, Lin S, Wu X, Esterman M, Koger D, Hanson J, Higgs R, Liu F, Malkani S, Bales KR et al.. 2004. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.. Nat Med. 10(7):719-26.

Koistinaho M, Lin S, Wu X, Esterman M, Koger D, Hanson J, Higgs R, Liu F, Malkani S, Bales KR et al.. 2004. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.. Nat Med. 10(7):719-26.

Gresch O, Engel FB, Nesic D, Tran TThai, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S et al.. 2004. New non-viral method for gene transfer into primary cells.. Methods. 33(2):151-63.

Gresch O, Engel FB, Nesic D, Tran TThai, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S et al.. 2004. New non-viral method for gene transfer into primary cells.. Methods. 33(2):151-63.

2003

Ford BD, Liu Y, Mann MAnne, Krauss R, Phillips K, Gan L, Fischbach GD. 2003. Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes.. Biochem Biophys Res Commun. 308(1):23-8.

Luo W-jie, Wang H, Li H, Kim BS, Shah S, Lee H-J, Thinakaran G, Kim T-W, Yu G, Xu H. 2003. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.. J Biol Chem. 278(10):7850-4.

Luo W-jie, Wang H, Li H, Kim BS, Shah S, Lee H-J, Thinakaran G, Kim T-W, Yu G, Xu H. 2003. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.. J Biol Chem. 278(10):7850-4.

2002

Bhattacharjee A, Gan L, Kaczmarek LK. 2002. Localization of the Slack potassium channel in the rat central nervous system.. J Comp Neurol. 454(3):241-54.

2001

Reichlin A, Hu Y, Meffre E, Nagaoka H, Gong S, Kraus M, Rajewsky K, Nussenzweig MC. 2001. B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta.. J Exp Med. 193(1):13-23.

Rho J, Gong S, Kim N, Choi Y. 2001. TDAG51 is not essential for Fas/CD95 regulation and apoptosis in vivo.. Mol Cell Biol. 21(24):8365-70.

2000

Kronin V, Wu L, Gong S, Nussenzweig MC, Shortman K. 2000. DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses.. Int Immunol. 12(5):731-5.