Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 360 results
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2023
Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, Tu J, Li T, Leitz J, Pfuetzner RA et al..  2023.  Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.. Proc Natl Acad Sci U S A. 120(44):e2310174120.
Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, Tu J, Li T, Leitz J, Pfuetzner RA et al..  2023.  Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.. Proc Natl Acad Sci U S A. 120(44):e2310174120.
Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, Tu J, Li T, Leitz J, Pfuetzner RA et al..  2023.  Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.. Proc Natl Acad Sci U S A. 120(44):e2310174120.
Oliveros G, Wallace CH, Chaudry O, Liu Q, Qiu Y, Xie L, Rockwell P, Figueiredo-Pereira ME, Serrano PA.  2023.  Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation.. Brain. 146(3):898-911.
Liao Z, Xie L, Mamitsuka H, Zhu S.  2023.  Sc2Mol: a scaffold-based two-step molecule generator with variational autoencoder and transformer.. Bioinformatics. 39(1)
Lopez-Lee C, Kodama L, Fan L, Wong MYing, Foxe NR, Jiaz L, Yu F, Ye P, Zhu J, Norman K et al..  2023.  Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging.. bioRxiv.
Lopez-Lee C, Kodama L, Fan L, Wong MYing, Foxe NR, Jiaz L, Yu F, Ye P, Zhu J, Norman K et al..  2023.  Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging.. bioRxiv.
Lopez-Lee C, Kodama L, Fan L, Wong MYing, Foxe NR, Jiaz L, Yu F, Ye P, Zhu J, Norman K et al..  2023.  Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging.. bioRxiv.
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERuth S, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G et al..  2023.  Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.. Nat Neurosci. 26(5):737-750.
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERuth S, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G et al..  2023.  Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.. Nat Neurosci. 26(5):737-750.
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERuth S, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G et al..  2023.  Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.. Nat Neurosci. 26(5):737-750.
Zhang S, Liu Y, Xie L.  2023.  A universal framework for accurate and efficient geometric deep learning of molecular systems.. Sci Rep. 13(1):19171.
2022
Pham T-H, Qiu Y, Liu J, Zimmer S, O'Neill E, Xie L, Zhang P.  2022.  Chemical-induced gene expression ranking and its application to pancreatic cancer drug repurposing.. Patterns (N Y). 3(4):100441.
Dräger NM, Sattler SM, Huang CTzu-Ling, Teter OM, Leng K, Hashemi SHadi, Hong J, Aviles G, Clelland CD, Zhan L et al..  2022.  A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.. Nat Neurosci.
Wu Y, Liu Q, Qiu Y, Xie L.  2022.  Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer's disease drug repurposing.. PLoS Comput Biol. 18(8):e1010367.
Cai T, Abbu KAlyssa, Liu Y, Xie L.  2022.  DeepREAL: a deep learning powered multi-scale modeling framework for predicting out-of-distribution ligand-induced GPCR activity.. Bioinformatics. 38(9):2561-2570.
Liu Y, Lim H, Xie L.  2022.  Exploration of chemical space with partial labeled noisy student self-training and self-supervised graph embedding.. BMC Bioinformatics. 23(Suppl 3):158.
Liu Y, Lim H, Xie L.  2022.  Exploration of chemical space with partial labeled noisy student self-training and self-supervised graph embedding.. BMC Bioinformatics. 23(Suppl 3):158.
Xie YXue, Naseri NN, Fels J, Kharel P, Na Y, Lane D, Burré J, Sharma M.  2022.  Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.. Nat Commun. 13(1):4918.
Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al..  2022.  Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.
Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al..  2022.  Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.
Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al..  2022.  Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.
Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al..  2022.  Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.
Kuo S-H, Tasset I, Cheng MM, Diaz A, Pan M-K, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P et al..  2022.  Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.. Sci Adv. 8(6):eabm6393.
Kuo S-H, Tasset I, Cheng MM, Diaz A, Pan M-K, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P et al..  2022.  Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.. Sci Adv. 8(6):eabm6393.