Friend turned foe: TREM2 agonist in battles against tau.

TitleFriend turned foe: TREM2 agonist in battles against tau.
Publication TypeJournal Article
Year of Publication2023
AuthorsCarling G, Luo W, Gan L
JournalJ Exp Med
Date Published2023 Jan 02
KeywordsAlzheimer Disease, Animals, Friends, Graft vs Host Disease, Humans, Membrane Glycoproteins, Mice, Microglia, Receptors, Immunologic

In this important study, Jain et al. (2022. J. Exp. Med. find that chronic TREM2 activation by AL002a antibody exacerbates the seeding and spread of pathological tau, enhances the disease-associated microglial signature, and increases neurite dystrophy in 5xFAD mice seeded with Alzheimer's disease tau.

Alternate JournalJ Exp Med
PubMed ID36399126
PubMed Central IDPMC9680035