| Title | Friend turned foe: TREM2 agonist in battles against tau. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Carling G, Luo W, Gan L |
| Journal | J Exp Med |
| Volume | 220 |
| Issue | 1 |
| Date Published | 2023 Jan 02 |
| ISSN | 1540-9538 |
| Keywords | Alzheimer Disease, Animals, Friends, Graft vs Host Disease, Humans, Membrane Glycoproteins, Mice, Microglia, Receptors, Immunologic |
| Abstract | In this important study, Jain et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220654) find that chronic TREM2 activation by AL002a antibody exacerbates the seeding and spread of pathological tau, enhances the disease-associated microglial signature, and increases neurite dystrophy in 5xFAD mice seeded with Alzheimer's disease tau. |
| DOI | 10.1084/jem.20221850 |
| Alternate Journal | J Exp Med |
| PubMed ID | 36399126 |
| PubMed Central ID | PMC9680035 |